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Literature summary extracted from

  • Baskin, F.K.; Kitachi, A.E.
    Substrate studies for insulin-specific protease (1973), Eur. J. Biochem., 37, 489-496.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.56 0.0000158
-
 desalanine-insulin
-
 Rattus norvegicus
3.4.24.56 0.000022
-
 Insulin
-
 Rattus norvegicus
3.4.24.56 0.0000244
-
 monoarginine-insulin diarginine-insulin Rattus norvegicus
3.4.24.56 0.000044
-
 destridecapeptide-proinsulin
-
 Rattus norvegicus
3.4.24.56 0.000055
-
 desnonapeptide-proinsulin
-
 Rattus norvegicus
3.4.24.56 0.000176
-
 desdipeptide-proinsulin
-
 Rattus norvegicus
3.4.24.56 0.0002342
-
 Proinsulin cleaved Rattus norvegicus
3.4.24.56 0.0008572
-
 Proinsulin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.56 soluble
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.56
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 desalanine-insulin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 desdipeptide-proinsulin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 desnonapeptide-proinsulin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 destridecapeptide-proinsulin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 Insulin + H2O
-
 Rattus norvegicus Hydrolyzed insulin
-
 ?
3.4.24.56 monoarginine-insulin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 additional information requirement for optimal substrate activity is the deblocking of the amino end of the A-chain Rattus norvegicus ?
-
 ?
3.4.24.56 Porcine proinsulin intermediates + H2O cleaved proinsulin, desdipeptide-proinsulin, desnonapeptide-proinsulin, destridecapeptide-proinsulin, desalanine-insulin, monoarginine-insulin and diarginine-proinsulin are degraded at 19.8%, 25.6%, 63.5%, 73.7%, 101.5%, 98% and 98% of the activity of insulin, respectively Rattus norvegicus ?
-
 ?