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Literature summary extracted from

  • Galloway, W.A.; Murphy, G.; Sandy, J.D.; Gavrilovic, J.; Cawston, T.E.; Reanolds, J.J.
    Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components (1983), Biochem. J., 209, 741-752.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.17 1,10-phenanthroline
-
 Oryctolagus cuniculus
3.4.24.17 DTT partial Oryctolagus cuniculus
3.4.24.17 EDTA
-
 Oryctolagus cuniculus
3.4.24.17 additional information diisopropylphosphofluoridate; pepstatin; phenylmethanesulfonyl fluoride; soybean trypsin inhibitor Oryctolagus cuniculus
3.4.24.17 Specific metalloproteinase inhibitor bovine-nasal cartilage extract; isolated from human amniotic fluid; rabbit bone culture medium Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.17 extracellular
-
 Oryctolagus cuniculus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.17 12500
-
 x * 12500, rabbit, SDS-PAGE Oryctolagus cuniculus
3.4.24.17 24500
-
 gel filtration Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.17 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.17
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.17 culture medium of bone Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.17 additional information
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.17 2,4-Dinitrophenyl-Pro-Leu-Gly-Ile-Ala-Gly-Arg-NH2 + H2O
-
 Oryctolagus cuniculus ?
-
 ?
3.4.24.17 casein + H2O
-
 Oryctolagus cuniculus ?
-
 ?
3.4.24.17 Collagen type III + H2O
-
 Oryctolagus cuniculus ?
-
 ?
3.4.24.17 Collagen type IV + H2O
-
 Oryctolagus cuniculus More
-
 ?
3.4.24.17 Fibronectin + H2O
-
 Oryctolagus cuniculus Intact fibronectin subunit MW 22000 + a disulfide-bonded COOH-terminal MW 20000 polypeptide
-
 ?
3.4.24.17 Laminin + H2O
-
 Oryctolagus cuniculus ?
-
 ?
3.4.24.17 additional information cleavage at multiple chondroitin sulfate-binding sites along the protein core Oryctolagus cuniculus ?
-
 ?
3.4.24.17 Procollagen + H2O removal of the NH2-terminal propeptides Oryctolagus cuniculus ?
-
 ?
3.4.24.17 Proteoglycan + H2O
-
 Oryctolagus cuniculus More
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.17 ? x * 12500, rabbit, SDS-PAGE Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.24.17 5 9 active over this range against various substrates Oryctolagus cuniculus