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Literature summary extracted from

  • MacKay, V.L.; Welch, S.K.; Insley, M.Y.; Manney, T.R.; Holly, J.; Saari, G.C.; Parker, M.L.
    The Saccharomyces cerevisiae BAR1 gene encodes an exported protein with homology to pepsin (1988), Proc. Natl. Acad. Sci. USA, 85, 55-59.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.23.35 Saccharomyces cerevisiae, by in vivo complementation of a bar1 mutation in yeast strain XP635-10C Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.35 additional information no inhibition by EDTA, 6-aminohexanoic acid, PMSF, aprotinin, leupeptin, tosyl-Lys methyl ester, pepstatin A Saccharomyces cerevisiae
3.4.23.35 tosyl-Arg methyl ester not Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.35 extracellular
-
 Saccharomyces cerevisiae
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.35 alpha Factor + H2O Saccharomyces cerevisiae i.e. Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr, involved in physiological changes preceding Saccharomyces cerevisiae cell fusion ?
-
 ?
3.4.23.35 alpha Factor + H2O Saccharomyces cerevisiae acts as antagonist of alpha factor, the peptide mating pheromone produced by mating type alpha-cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.35 Saccharomyces cerevisiae
-
 baker's yeast mutant strains
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.35 alpha Factor + H2O cleavage site: Leu6-Lys7 Saccharomyces cerevisiae Trp-His-Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
 ?
3.4.23.35 alpha Factor + H2O i.e. Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr, a Saccharomyces cerevisiae peptide mating pheromone secreted by mating-type alpha cells Saccharomyces cerevisiae Trp-His-Trp-Leu-Gln-Leu + Lys-Pro-Gly-Gln-Pro-Met-Tyr
-
 ?
3.4.23.35 alpha Factor + H2O i.e. Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr, involved in physiological changes preceding Saccharomyces cerevisiae cell fusion Saccharomyces cerevisiae ?
-
 ?
3.4.23.35 alpha Factor + H2O acts as antagonist of alpha factor, the peptide mating pheromone produced by mating type alpha-cells Saccharomyces cerevisiae ?
-
 ?