EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.23.20 | Leu-Gly-Leu | inhibits trypsinogen activation, activates cleavage of Leu-Tyr amide | Penicillium janthinellum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.23.20 | 1,2-epoxy-3-(4-nitrophenoxy)propane | - |
Penicillium janthinellum | |
3.4.23.20 | Benzyloxycarbonyl-Gln-Tyr | - |
Penicillium janthinellum | |
3.4.23.20 | Benzyloxycarbonyl-Glu | - |
Penicillium janthinellum | |
3.4.23.20 | Benzyloxycarbonyl-Val-Tyr | - |
Penicillium janthinellum | |
3.4.23.20 | Diazoacetyl DL-norleucine methyl ester | in presence of Cu2+ | Penicillium janthinellum | |
3.4.23.20 | K2PtCl6 | partial | Penicillium janthinellum | |
3.4.23.20 | Leu-Gly-Leu | inhibits trypsinogen activation, activates cleavage of Leu-Tyr amide | Penicillium janthinellum | |
3.4.23.20 | additional information | benzyloxycarbonyl-Phe; not: benzyloxycarbonyl-Tyr; p-bromophenacylbromide | Penicillium janthinellum | |
3.4.23.20 | pepstatin | - |
Penicillium janthinellum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.20 | 0.0076 | - |
Trypsinogen | - |
Penicillium janthinellum |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.23.20 | extracellular | - |
Penicillium janthinellum | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.23.20 | additional information | - |
homologue of: chymosin | Penicillium janthinellum |
3.4.23.20 | additional information | - |
homologue of: pepsin (mammalian) | Penicillium janthinellum |
3.4.23.20 | 32000 | - |
Penicillium janthinellum | Penicillium janthinellum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.23.20 | Penicillium janthinellum | - |
NRRL 905, C.M.I. 75589 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.23.20 | - |
Penicillium janthinellum |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.23.20 | additional information | - |
- |
Penicillium janthinellum |
EC Number | Storage Stability | Organism |
---|---|---|
3.4.23.20 | Room temperature, pH 4.9, several days | Penicillium janthinellum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.20 | B-chain of S-sulfo-insulin + H2O | - |
Penicillium janthinellum | ? | - |
? | |
3.4.23.20 | Bovine serum albumin + H2O | cleaves 15% of the peptide bonds | Penicillium janthinellum | ? | - |
? | |
3.4.23.20 | bovine trypsinogen + H2O | - |
Penicillium janthinellum | ? | - |
? | |
3.4.23.20 | additional information | acts on some small substrates with two hydrophobic amino acids at the N-terminus and a free amino group, in addition to removing the N-terminal amino acid hydrolytically a trans-peptidation reaction occurs: Leu-Leu is formed from Leu-Tyr-Leu, Phe-Phe from Phe-Tyr-Thr-Pro-Lys-Ala and Met-Met from Met-Leu-Gly | Penicillium janthinellum | ? | - |
? | |
3.4.23.20 | Trypsinogen + H2O | bovine, activation by cleavage of Lys6-Ile7 | Penicillium janthinellum | ? | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.23.20 | 37 | - |
pH 3.0 or pH 6.1, slow inactivation | Penicillium janthinellum |
3.4.23.20 | 55 | - |
pH 4.9, 1 h, stable | Penicillium janthinellum |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.20 | 5 | - |
bovine trypsinogen | - |
Penicillium janthinellum |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.23.20 | 2.6 | - |
bovine serum albumin | Penicillium janthinellum |
3.4.23.20 | 3.4 | - |
trypsinogen | Penicillium janthinellum |
3.4.23.20 | 3.6 | - |
hydrolysis and transpeptidation of small substrates | Penicillium janthinellum |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
3.4.23.20 | 2 | 7 | rapid loss of activity below pH 2.0 and above pH 7.0 | Penicillium janthinellum |
3.4.23.20 | 3 | - |
37°C, slow inactivation | Penicillium janthinellum |
3.4.23.20 | 4.9 | - |
55°C, 1 h, stable | Penicillium janthinellum |
3.4.23.20 | 6.1 | - |
37°C, slow inactivation | Penicillium janthinellum |