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Literature summary extracted from

  • Loh, Y.P.; Gainer, H.
    Characterization of pro-opiocortin-converting activity in purified secretory granules from rat pituitary neurointermediate lobe (1982), Proc. Natl. Acad. Sci. USA, 79, 108-112.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.17 leupeptin
-
 Rattus norvegicus
3.4.23.17 additional information chloroquine; EDTA; Nalpha-p-tosyl-L-lysine chloromethylketone hydrochloride; not: diisopropyl fluorophosphate Rattus norvegicus
3.4.23.17 PCMB
-
 Rattus norvegicus
3.4.23.17 pepstatin A
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.17 membrane
-
 Rattus norvegicus 16020
-
3.4.23.17 soluble
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.17 hypophysis intermediate Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.17 Pro-opiomelanocortin + H2O
-
 Rattus norvegicus Adrenocorticotropin + beta-lipotropin + alpha-melanotropin MW 16000 + NH2-terminal glycopeptide + an endorphin-related peptide ?
3.4.23.17 Pro-opiomelanocortin + H2O
-
 Rattus norvegicus Adrenocorticotropin + beta-lipotropin ACTH of MW 21000 and 13000 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.17 5
-
 crude enzyme extract Rattus norvegicus