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Literature summary extracted from

  • Schmitt, M.; Jänicke, F.; Moniwa, N.; Chucholowski, N.; Pache, L.; Graeff, H.
    Tumor-associated urokinase-type plasminogen activator: biological and clinical significance (1992), Biol. Chem. Hoppe-Seyler, 373, 611-622.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 plasminogen activator inhibitor 1
-
 Homo sapiens
3.4.21.73 Plasminogen activator inhibitor 2
-
 Homo sapiens
3.4.21.73 Protease nexin I
-
 Homo sapiens
3.4.21.73 Protein C inhibitor
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.73 additional information
-
 plasmin, plasma kallikrein, trypsin, thermolysin and cathepsin B and L cleave pro-uPA at the peptide bond Lys158-Ile159 which converts pro-uPA into the enzymatically active high-molecular weight two-chain form Homo sapiens
3.4.21.73 52000
-
 human, high-molecular weight two-chain form Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens the enzyme mediates pericellular proteolysis during cell migration and tissue remodelling under physiological and pathophysiological conditions ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 alveolar cell
-
 Homo sapiens
-
3.4.21.73 fibroblast
-
 Homo sapiens
-
3.4.21.73 keratinocyte
-
 Homo sapiens
-
3.4.21.73 kidney tubule cells Homo sapiens
-
3.4.21.73 phagocyte granulocytes, monocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
3.4.21.73 plasminogen + H2O the enzyme mediates pericellular proteolysis during cell migration and tissue remodelling under physiological and pathophysiological conditions Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.73 More the two-polypeptide of the high-molecular-weight two-chain form are linked by disulfide bonds Homo sapiens
3.4.21.73 More A-chain MW 20000 and B-chain MW 32000 Homo sapiens