Literature summary extracted from

Hu, C.K.; Kohnert, U.; Sturzebecher, J.; Fischer, S.; Llinas, M.
Complexation of the tissue plasminogen activator protease with benzamidine-type inhibitors: interference by the kringle 2 module (1996), Biochemistry, 35, 3270-3276.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.68	2,5-Bis(4-amidinobenzylidene)cyclopentanone	-	Homo sapiens
3.4.21.68	2,6-Bis(4-amidinobenzylidene)cyclohexanone	-	Homo sapiens
3.4.21.68	2,7-Bis(4-amidinobenzylidene)cycloheptanone	-	Homo sapiens
3.4.21.68	2,8-Bis(4-amidinobenzylidene)cyclooctanone	-	Homo sapiens
3.4.21.68	benzamidine	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.68	Homo sapiens	-	recombinant protease and BM 06.022 proteins expressed in Escherichia coli	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.68	plasminogen + H2O	-	Homo sapiens	plasmin + ?	-	?

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Release 2023.1 (January 2023)