Any feedback?
Literature summary extracted from
- Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (taipan venom) (1980), Biochemistry, 19, 1020-1023.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.60 | Phospholipid | stimulates activation of both prothrombin and prethrombin 2, activation of prethrombin 1 is insensitive | Oxyuranus scutellatus |  |
| 3.4.21.60 | Prothrombin fragment 2 | stimulates activation of prethrombin 2 | Oxyuranus scutellatus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.60 | benzamidine | inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide | Oxyuranus scutellatus | |
| 3.4.21.60 | Bovine pancreas trypsin inhibitor | inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide | Oxyuranus scutellatus | |
| 3.4.21.60 | Inhibitor present in the venom of Oxyuranus scutellatus | inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide | Oxyuranus scutellatus | |
| 3.4.21.60 | additional information | hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4nitroanilide is insensitive to: diisopropyl fluorophosphate, antithrombin III, chicken ovomucoid trypsin inhibitor, EDTA, 1,10-phenanthroline, activated protein C | Oxyuranus scutellatus | |
| 3.4.21.60 | NaCl | inhibits activation of prethrombin 2, no effect on reaction with meizothrombin | Oxyuranus scutellatus | |
| 3.4.21.60 | Nalpha-p-toluenesulfonyl-L-Arg methyl ester | inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide | Oxyuranus scutellatus | |
| 3.4.21.60 | Soybean trypsin inhibitor | inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide | Oxyuranus scutellatus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.60 | prothrombin + H2O | Oxyuranus scutellatus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.60 | Oxyuranus scutellatus | - |
Taipan snake | - |
| 3.4.21.60 | Oxyuranus scutellatus | - |
scutellatus | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.60 | venom | - |
Oxyuranus scutellatus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.60 | benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide + H2O | - |
Oxyuranus scutellatus | benzoyl-Ile-Glu-Gly-Arg + 4-nitroaniline | - |
? | |
| 3.4.21.60 | Meizothrombin + H2O | des fragment 1 | Oxyuranus scutellatus | ? | - |
? | |
| 3.4.21.60 | additional information | no hydrolysis of: benzoyl-Phe-Arg 4-nitroanilide, D-Val-Leu-Lys 4-nitroanilide | Oxyuranus scutellatus | ? | - |
? | |
| 3.4.21.60 | Prethrombin 1 + H2O | - |
Oxyuranus scutellatus | ? | - |
? | |
| 3.4.21.60 | Prethrombin 2 + H2O | - |
Oxyuranus scutellatus | ? | - |
? | |
| 3.4.21.60 | prothrombin + H2O | - |
Oxyuranus scutellatus | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.60 | 7.5 | 8 | hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide | Oxyuranus scutellatus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
