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Literature summary extracted from

  • Song, L.; Fricker, L.D.
    Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D (1996), J. Biol. Chem., 271, 28884-28889.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.22 1,10-phenanthroline
-
 Bos taurus
3.4.17.22 CdCl2
-
 Bos taurus
3.4.17.22 CuSO4
-
 Bos taurus
3.4.17.22 EDTA
-
 Bos taurus
3.4.17.22 EGTA
-
 Bos taurus
3.4.17.22 Guanidinoethylmercaptosuccinic acid i.e. GEMSA Bos taurus
3.4.17.22 HgCl2
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.17.22 0.042
-
 dansyl-Phe-Leu-Arg soluble enzyme Bos taurus
3.4.17.22 0.052
-
 Dansyl-Pro-Ala-Arg membrane-bound enzyme Bos taurus
3.4.17.22 0.053
-
 Dansyl-Pro-Ala-Arg soluble enzyme Bos taurus
3.4.17.22 0.054
-
 Dansyl-Pro-Ala-Arg dansyl-Phe-Leu-Arg, membrane- bound enzyme Bos taurus
3.4.17.22 0.064
-
 Dansyl-Leu-Ala-Arg membrane-bound enzyme Bos taurus
3.4.17.22 0.065
-
 Dansyl-Leu-Ala-Arg soluble enzyme Bos taurus
3.4.17.22 0.073
-
 dansyl-Phe-Ala-Arg membrane-bound enzyme Bos taurus
3.4.17.22 0.087
-
 dansyl-Phe-Ala-Arg soluble enzyme Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.22 cytosol 19% of total activity Bos taurus 5829
-
3.4.17.22 membrane
-
 Bos taurus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.17.22 135000
-
 deglycosaylated enzyme Bos taurus
3.4.17.22 170000
-
 glycosylated enzyme Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.22 additional information Bos taurus production of growth factors and/or growth factor receptors, processing of peptide hormones ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.22 Bos taurus
-
-
-
3.4.17.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.17.22
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.22 adrenal gland
-
 Rattus norvegicus
-
3.4.17.22 brain
-
 Rattus norvegicus
-
3.4.17.22 cerebellum
-
 Rattus norvegicus
-
3.4.17.22 cerebral cortex
-
 Rattus norvegicus
-
3.4.17.22 corpus striatum
-
 Rattus norvegicus
-
3.4.17.22 heart
-
 Rattus norvegicus
-
3.4.17.22 hypophysis
-
 Rattus norvegicus
-
3.4.17.22 hypophysis
-
 Bos taurus
-
3.4.17.22 hypothalamus
-
 Rattus norvegicus
-
3.4.17.22 kidney
-
 Rattus norvegicus
-
3.4.17.22 liver
-
 Rattus norvegicus
-
3.4.17.22 lung
-
 Rattus norvegicus
-
3.4.17.22 placenta
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.22 Dansyl-Leu-Ala-Arg + H2O
-
 Bos taurus Dansyl-Leu-Ala + Arg
-
 ?
3.4.17.22 Dansyl-Phe-Ala-Arg + H2O
-
 Bos taurus Dansyl-Phe-Ala + Arg
-
 ?
3.4.17.22 Dansyl-Phe-Leu-Arg + H2O
-
 Bos taurus Dansyl-Phe-Leu + Arg
-
 ?
3.4.17.22 Dansyl-Pro-Ala-Arg + H2O
-
 Bos taurus Dansyl-Pro-Ala + Arg
-
 ?
3.4.17.22 additional information production of growth factors and/or growth factor receptors, processing of peptide hormones Bos taurus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.22 5.5 6.5 soluble enzyme Bos taurus