Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Timm, D.E.; Mueller, H.A.; Bhanumoorthy, P.; Harp, J.M.; Bunick, G.J.
    Crystal structure and mechanism of a carbon-carbon bond hydrolase (1999), Structure, 7, 1023-1033.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.7.1.2 medicine plays a role in hereditary tyrosinemia Mus musculus
3.7.1.2 medicine plays a role in degradation pathway of phenylalanine and tyrosine Mus musculus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.7.1.2
-
 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.7.1.2 A134D
-
 Mus musculus
3.7.1.2 C193R mutant may affect the active-site geometry Mus musculus
3.7.1.2 D233V mutant Mus musculus
3.7.1.2 G158D mutant may affect the active-site geometry Mus musculus
3.7.1.2 G158D mutant may affect the active site by perturbing the FAH quarternary structure Mus musculus
3.7.1.2 G207D mutant may affect the active-site geometry Mus musculus
3.7.1.2 G369V mutant may affect the active-site geometry Mus musculus
3.7.1.2 N16I mutant may disrupt activity by causing misfolding Mus musculus
3.7.1.2 P249T mutant may affect the active-site geometry Mus musculus
3.7.1.2 P261L mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions Mus musculus
3.7.1.2 P342L mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions Mus musculus
3.7.1.2 S405H mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions Mus musculus
3.7.1.2 V166G mutant may affect the active-site geometry Mus musculus
3.7.1.2 W234G mutant may affect the active-site geometry Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.7.1.2 Ca2+
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.7.1.2 46000
-
 2 * 46000 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.7.1.2 4-fumarylacetoacetate + H2O Mus musculus
-
 acetoacetate + fumarate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.2 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.7.1.2
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.2 4-fumarylacetoacetate + H2O
-
 Mus musculus acetoacetate + fumarate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.7.1.2 dimer 2 * 46000 Mus musculus