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Literature summary extracted from
- Interaction of steroids with Pseudomonas testosteroni 3-oxosteroid DELTA4-DELTA5 isomerase (1977), Biochemistry, 16, 5045-5053.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.3.1 | 3-Deoxyestradiol | mixed noncompetitive | Comamonas testosteroni |  |
| 5.3.3.1 | 4,4'-Dihydroxy-2',7'-dimethyl-7-ethyl-trans-stilbene | noncompetitive | Comamonas testosteroni | |
| 5.3.3.1 | 4,4'-Dihydroxy-2',7-dimethyl-7'-ethyl-trans-stilbene | competitive | Comamonas testosteroni | |
| 5.3.3.1 | coumestrol | mixed noncompetitive | Comamonas testosteroni | |
| 5.3.3.1 | diethylstilbestrol | competitive | Comamonas testosteroni | |
| 5.3.3.1 | estradiol | competitive | Comamonas testosteroni | |
| 5.3.3.1 | estrone | and derivatives, noncompetitive | Comamonas testosteroni | |
| 5.3.3.1 | additional information | overview: interaction of the enzyme with steroids | Comamonas testosteroni |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.3.1 | Comamonas testosteroni | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 5.3.3.1 | a 3-oxo-DELTA5-steroid = a 3-oxo-DELTA4-steroid | "flip-flop" mechanism may be involved | Comamonas testosteroni |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.3.1 | 5-Androstene-3,17-dione | - |
Comamonas testosteroni | 4-Androstene-3,17-dione | - |
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