EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.3.18 | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.3.18 | 0.51 | - |
NG-monomethyl-L-arginine | DDAH I | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.3.18 | Homo sapiens | O95865 | 2 dimethylarginine dimethylaminohydrolases: DDAH I and II | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.3.18 | brain | DDAH I is highly expressed | Homo sapiens | - |
3.5.3.18 | heart | DDAH II is highly expressed | Homo sapiens | - |
3.5.3.18 | kidney | DDAH I and DDAH II are highly expressed | Homo sapiens | - |
3.5.3.18 | liver | DDAH I is highly expressed, low level expression of DDAH II | Homo sapiens | - |
3.5.3.18 | lung | low level expression of DDAH II | Homo sapiens | - |
3.5.3.18 | additional information | DDAH I predominates in tissues that express neuronal nitric oxide synthase, DDAH II predominates in tissues expressing endothelial nitric oxide synthase | Homo sapiens | - |
3.5.3.18 | pancreas | DDAH I is highly expressed, low level expression of DDAH II | Homo sapiens | - |
3.5.3.18 | placenta | DDAH II is highly expressed | Homo sapiens | - |
3.5.3.18 | skeletal muscle | DDAH I and II is expressed at a low level | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.18 | additional information | no hydrolysis of NG,NĀG-dimethyl-L-arginine | Homo sapiens | ? | - |
? | |
3.5.3.18 | NG,NG-dimethyl-L-arginine + H2O | - |
Homo sapiens | dimethylamine + L-citrulline | - |
? | |
3.5.3.18 | NG-monomethyl-L-arginine + H2O | - |
Homo sapiens | citrulline + methylamine | - |
? |