EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.31 | delta-hydroxylysine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans | |
1.2.1.31 | L-lysine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans | |
1.2.1.31 | S-(beta-aminoethyl)-L-cysteine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.31 | 0.23 | - |
NADPH | - |
Blastobotrys adeninivorans | |
1.2.1.31 | 0.77 | - |
MgCl2 | - |
Blastobotrys adeninivorans | |
1.2.1.31 | 0.78 | - |
alpha-aminoadipate | - |
Blastobotrys adeninivorans | |
1.2.1.31 | 1 | - |
ATP | - |
Blastobotrys adeninivorans |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.31 | Mg2+ | required for activity | Blastobotrys adeninivorans |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | Blastobotrys adeninivorans | in presence of ATP and Mg2+ | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | Blastobotrys adeninivorans | sixth step of lysine biosynthesis | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.31 | Blastobotrys adeninivorans | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.31 | using DEAE-cellulose column chromatography | Blastobotrys adeninivorans |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.31 | additional information | - |
- |
Blastobotrys adeninivorans |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.31 | alpha-aminoadipic semialdehyde + NAD+ + H2O | - |
Blastobotrys adeninivorans | alpha-aminoadipic acid + NADH + H+ | - |
? | |
1.2.1.31 | L-2-aminoadipate + NADPH | in presence of ATP + Mg2+ | Blastobotrys adeninivorans | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | in presence of ATP and Mg2+ | Blastobotrys adeninivorans | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | sixth step of lysine biosynthesis | Blastobotrys adeninivorans | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.31 | 8 | 8.7 | - |
Blastobotrys adeninivorans |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.31 | NADPH | - |
Blastobotrys adeninivorans |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.31 | 0.007 | - |
S-(beta-aminoethyl)-L-cysteine | - |
Blastobotrys adeninivorans | |
1.2.1.31 | 0.09 | - |
L-lysine | - |
Blastobotrys adeninivorans | |
1.2.1.31 | 1.65 | - |
delta-hydroxylysine | - |
Blastobotrys adeninivorans |