EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.4 | dithiothreitol | - |
Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.4 | 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone | trivial name lapachol, 0.002 mM, 50% inhibition, liver microsomes from normal-strain, inhibition is fully reversible; trivial name lapachol, 50% inhibition of KO reductase activity in whole liver microsomes of warfarin-resistant rats, inhibition is fully reversible | Rattus norvegicus | |
1.17.4.4 | coumarin anticoagulants | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.17.4.4 | microsome | - |
Rattus norvegicus | - |
- |
1.17.4.4 | microsome | integral membrane protein | Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus | - |
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus Holtzman | - |
2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.4.4 | Rattus norvegicus | - |
- |
- |
1.17.4.4 | Rattus norvegicus | - |
Holtzman strain | - |
1.17.4.4 | Rattus norvegicus Holtzman | - |
Holtzman strain | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.17.4.4 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.4.4 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
Rattus norvegicus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Rattus norvegicus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. 3-hydroxy-2,3-dihydro-vitamin K | ? | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
Rattus norvegicus Holtzman | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | - |
? | |
1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Rattus norvegicus Holtzman | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. 3-hydroxy-2,3-dihydro-vitamin K | ? | |
1.17.4.4 | vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? | |
1.17.4.4 | vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus Holtzman | vitamin K + oxidized dithiothreitol | - |
? |