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Literature summary extracted from

  • Sato, R.; Goldstein, J.L.; Brown, M.S.
    Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion (1993), Proc. Natl. Acad. Sci. USA, 90, 9261-9265.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.88 expressed in COS-M6a, monkey Mesocricetus auratus
1.1.1.88 expressed in UT-2, CHO-cells Mesocricetus auratus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.88 S871A 150% of wild-type activity in 50 mM KCl Mesocricetus auratus

General Stability

EC Number General Stability Organism
1.1.1.88 stable to quick freezing and boiling Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.88 KF
-
 Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.88 endoplasmic reticulum membrane-bound Mesocricetus auratus 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.88 (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ Mesocricetus auratus mevalonate is required for cholesterol and isoprenoid synthesis (R)-mevalonate + NAD+ + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.88 Mesocricetus auratus
-
 chinese hamster
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.88 phosphoprotein near the C-terminus Mesocricetus auratus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.88 0.922
-
 wild-type enzyme, [14C]-mevalonate acylation Mesocricetus auratus
1.1.1.88 1.203
-
 S871A [14C]-mevalonate acylation Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.88 (R)-mevalonate + CoA + 2 NAD+
-
 Mesocricetus auratus (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
 ?
1.1.1.88 (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ mevalonate is required for cholesterol and isoprenoid synthesis Mesocricetus auratus (R)-mevalonate + NAD+ + CoA
-
 ?