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Literature summary extracted from

  • Dumont, M.; Luu-The, V.; de Lanoit, Y.; Labrie, F.
    Expression of human 17beta-hydroxysteroid dehydrogenase in mammalian cells (1992), J. Steroid Biochem. Mol. Biol., 41, 605-608.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.239 expressed in HeLa human cervical carcinoma cells and COS-1 monkey kidney tumor cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.239 testosterone + NAD+ Homo sapiens
-
 androst-4-ene-3,17-dione + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.239 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.239 adipose
-
 Homo sapiens
-
1.1.1.239 mammary gland
-
 Homo sapiens
-
1.1.1.239 ovary
-
 Homo sapiens
-
1.1.1.239 placenta
-
 Homo sapiens
-
1.1.1.239 prostate gland
-
 Homo sapiens
-
1.1.1.239 testis
-
 Homo sapiens
-
1.1.1.239 uterine endometrium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.239 11beta-hydroxytestosterone + NAD+
-
 Homo sapiens 11beta-hydroxyandrost-4-ene-3,17-dione + NADH
-
 r
1.1.1.239 estradiol + NAD+
-
 Homo sapiens estrone + NADH
-
 r
1.1.1.239 testosterone + NAD+
-
 Homo sapiens androst-4-ene-3,17-dione + NADH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.239 NAD+
-
 Homo sapiens