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Literature summary extracted from

  • Emundson, T.D.; Ashworth, J.M.
    6-phosphogluconate dehydrogenase and the assay of uridine diphosphate glucose pyrophosphorylase in the cellular slime mould Dictyostelium discoideum (1972), Biochem. J., 126, 593-600.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.44 glycylglycine
-
 Dictyostelium discoideum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.018
-
 NADP+
-
 Dictyostelium discoideum
1.1.1.44 0.04
-
 6-phosphogluconate
-
 Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Dictyostelium discoideum
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Dictyostelium discoideum
-
 cellular slime mould, strain NC-4, haploid
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.44 0°C, stable to freezing and thawing, incubated for 24 h retains at least 70% of its original activity Dictyostelium discoideum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Dictyostelium discoideum D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.44 8.6 8.8 both Tris and tricine buffers, more active in tricine buffers Dictyostelium discoideum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+ no reaction with NAD+ Dictyostelium discoideum