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Literature summary extracted from

  • Bukato, G.; Kochan, Z.; Swierczynski, J.
    Different regulatory properties of the cytosolic and mitochondrial forms of malic enzyme isolated from human brain (1995), Int. J. Biochem. Cell Biol., 27, 1003-1008.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.40 fumarate increases activity of the mitochondrial enzyme at low malate concentrations, no effect on the activity of the cytosolic enzyme Homo sapiens
1.1.1.40 succinate increases activity of the mitochondrial enzyme at low malate concentrations, no effect on the activity of the cytosolic enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.40 malate excess of malate inhibits the oxidative decarboxylation catalyzed by the cytosolic enzyme at pH 7.0, and below, decarboxylation catalyzed by mitochondrial enzyme is unaffected by the substrate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.40 0.6
-
 L-malate cytosolic enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.40 cytosol
-
 Homo sapiens 5829
-
1.1.1.40 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.40 additional information Homo sapiens one may speculate that in vivo the reaction catalyzed by cytosolic enzyme supplies dicarboxylic acids, anaplerotic function, for the formation of neurotransmitters while the mitochondrial enzyme regulates the flux rate via Krebs cycle by disposition of the tricarboxylic acid cycle intermediates, cataplerotic function ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.40 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.40 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.40 (S)-malate + NADP+
-
 Homo sapiens pyruvate + CO2 + NADPH
-
 ?
1.1.1.40 additional information one may speculate that in vivo the reaction catalyzed by cytosolic enzyme supplies dicarboxylic acids, anaplerotic function, for the formation of neurotransmitters while the mitochondrial enzyme regulates the flux rate via Krebs cycle by disposition of the tricarboxylic acid cycle intermediates, cataplerotic function Homo sapiens ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.40 NADP+ cofactor Homo sapiens