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Literature summary extracted from

  • Crow, K.E.; Braggins, T.J.; Hardman, M.J.
    Human liver cytosolic malate dehydrogenase: Purification, kinetic properties, and role in ethanol metabolism (1983), Arch. Biochem. Biophys., 225, 621-629.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.37 L-malate
-
 Homo sapiens
1.1.1.37 L-malate
-
 Rattus norvegicus
1.1.1.37 L-malate
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.37 cytosol
-
 Homo sapiens 5829
-
1.1.1.37 cytosol
-
 Rattus norvegicus 5829
-
1.1.1.37 cytosol
-
 Sus scrofa 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.37 72000
-
-
 Sus scrofa
1.1.1.37 72000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.37 malate + NAD+ Homo sapiens
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Rattus norvegicus
-
 oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+ Sus scrofa
-
 oxaloacetate + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.37 Homo sapiens
-
 human
-
1.1.1.37 Rattus norvegicus
-
 rat
-
1.1.1.37 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.37
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.37 heart
-
 Sus scrofa
-
1.1.1.37 liver
-
 Homo sapiens
-
1.1.1.37 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.37 46.5
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.1.1.37 4°C, purified enzyme remains stable for up to 1 month Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.37 (S)-malate + NAD+
-
 Homo sapiens oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Rattus norvegicus oxaloacetate + NADH + H+
-
 r
1.1.1.37 (S)-malate + NAD+
-
 Sus scrofa oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Homo sapiens oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Rattus norvegicus oxaloacetate + NADH + H+
-
 r
1.1.1.37 malate + NAD+
-
 Sus scrofa oxaloacetate + NADH + H+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Homo sapiens L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Rattus norvegicus L-malate + NAD+
-
 r
1.1.1.37 oxaloacetate + NADH
-
 Sus scrofa L-malate + NAD+
-
 r