EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.34 | expression in Escherichia coli | Haloferax volcanii |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.34 | (R)-3-hydroxy-3-methylglutaryl-CoA | competitive inhibitor | Haloferax volcanii | |
1.1.1.34 | lovastatin | - |
Haloferax volcanii |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.34 | 0.03 | - |
CoA | - |
Haloferax volcanii | |
1.1.1.34 | 0.032 | - |
NADPH | reduction of R,S-mevaldehyde | Haloferax volcanii | |
1.1.1.34 | 0.035 | - |
NADP+ | - |
Haloferax volcanii | |
1.1.1.34 | 0.06 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | - |
Haloferax volcanii | |
1.1.1.34 | 0.066 | - |
NADPH | - |
Haloferax volcanii | |
1.1.1.34 | 0.47 | - |
(R,S)-mevaldehyde | oxidative acylation of (R,S)-mevaldehyde | Haloferax volcanii | |
1.1.1.34 | 0.55 | - |
(R,S)-mevaldehyde | reduction of (R,S)-mevaldehyde | Haloferax volcanii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | Haloferax volcanii | - |
(R)-mevalonate + CoA + NADP+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.34 | Haloferax volcanii | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.34 | - |
Haloferax volcanii |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.34 | 24000 | - |
- |
Haloferax volcanii |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.34 | (R,S)-mevaldehyde + acetate | - |
Haloferax volcanii | ? | - |
? | |
1.1.1.34 | (R,S)-mevaldehyde + NADPH | - |
Haloferax volcanii | ? | - |
? | |
1.1.1.34 | (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Haloferax volcanii | (R)-mevalonate + 2 NADP+ + CoA | - |
? | |
1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Haloferax volcanii | (R)-mevalonate + CoA + NADP+ | - |
r |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.34 | 6 | - |
reduction of (R,S)-mevaldehyde | Haloferax volcanii |
1.1.1.34 | 7.3 | - |
- |
Haloferax volcanii |
1.1.1.34 | 8 | - |
oxidative acylation of (R,S)-mevaldehyde | Haloferax volcanii |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.34 | NADPH | - |
Haloferax volcanii |