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Literature summary extracted from
- Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates (1985), Biochem. Biophys. Res. Commun., 128, 1099-1107.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.220 | 6-pyruvoyltetrahydropterin + NADPH | Rattus norvegicus | involved in de novo biosynthesis of tetrahydrobiopterin | 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ | - |
? |  |
| 1.1.1.220 | 6-pyruvoyltetrahydropterin + NADPH | Bos taurus | involved in de novo biosynthesis of tetrahydrobiopterin | 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.220 | Bos taurus | - |
bovine | - |
| 1.1.1.220 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.220 | from brain | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.220 | adrenal medulla | - |
Bos taurus | - |
| 1.1.1.220 | brain | - |
Rattus norvegicus | - |
| 1.1.1.220 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.220 | 0.0000159 | - |
- |
Bos taurus |
| 1.1.1.220 | 0.000021 | - |
liver | Rattus norvegicus |
| 1.1.1.220 | 0.0000514 | - |
brain | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.220 | 6-pyruvoyltetrahydropterin + NADPH | - |
Rattus norvegicus | 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ | - |
? | |
| 1.1.1.220 | 6-pyruvoyltetrahydropterin + NADPH | - |
Bos taurus | 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ | - |
? | |
| 1.1.1.220 | 6-pyruvoyltetrahydropterin + NADPH | involved in de novo biosynthesis of tetrahydrobiopterin | Rattus norvegicus | 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ | - |
? | |
| 1.1.1.220 | 6-pyruvoyltetrahydropterin + NADPH | involved in de novo biosynthesis of tetrahydrobiopterin | Bos taurus | 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ | - |
? | |
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