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Literature summary extracted from

  • Hempel, J.; Perozich, J.; Romovacek, H.; Hinich, A.; Kuo, I.; Feingold, D.S.
    UDP-glucose dehydrogenase from bovine liver: primary structure and relationship to other dehydrogenases (1994), Protein Sci., 3, 1074-1080.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.22 additional information comparison of sequence homologies with bacterial enzymes Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.22 additional information no metal ion requirement Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.22 52000
-
 6 * 52000, gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.22 UDPglucose + NAD+ + H2O Bos taurus
-
 UDPglucuronate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.22 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.22
-
 Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.22 UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+ reaction mechanism, C275 provides SH-group in the catalytic centre Bos taurus
a
1.1.1.22 UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+ also shows aldehyde dehydrogenase activity Bos taurus
a
1.1.1.22 UDP-alpha-D-glucose + 2 NAD+ + H2O = UDP-alpha-D-glucuronate + 2 NADH + 2 H+ also shows alcohol dehydrogenase activity Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.22 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.22 UDP-glucose + 2 NAD+ + H2O
-
 Bos taurus UDP-glucuronate + 2 NADH + 2 H+
-
 ?
1.1.1.22 UDPglucose + NAD+ + H2O
-
 Bos taurus UDPglucuronate + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.22 hexamer 6 * 52000, gel filtration Bos taurus