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Literature summary extracted from

  • Yamano, S.; Takahashi, A.; Todaka, T.; Toki, S.
    In vivo and in vitro formation of morphinone from morphine in rat (1997), Xenobiotica, 27, 645-656.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.218 5alpha-dihydrotestosterone
-
 Rattus norvegicus
1.1.1.218 5beta-dihydrotestosterone
-
 Rattus norvegicus
1.1.1.218 androsterone
-
 Rattus norvegicus
1.1.1.218 estradiol
-
 Rattus norvegicus
1.1.1.218 additional information no or weak inhibition by pyrazole, barbital Rattus norvegicus
1.1.1.218 quercetin
-
 Rattus norvegicus
1.1.1.218 testosterone
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.218 2.9
-
 morphine cosubstrate NAD+, in the male adult rats Rattus norvegicus
1.1.1.218 3.3
-
 morphine cosubstrate NAD+, in the female adult rats Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.218 microsome microsomal fraction Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.218 Rattus norvegicus
-
 Wistar
-
1.1.1.218 Rattus norvegicus Wistar
-
 Wistar
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.218 bile
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.218 morphine + NADP+ + NAD+: enzyme activity ten times that with NADP+ Rattus norvegicus morphinone + NADPH + H+
-
 ?
1.1.1.218 morphine + NADP+ + NAD+: enzyme activity ten times that with NADP+ Rattus norvegicus Wistar morphinone + NADPH + H+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.218 9.3
-
 in different buffers Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.218 NAD+ NADP+: only about one-tenth of activity with NAD+ Rattus norvegicus