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Literature summary extracted from

  • Carpenter, K.; Pollitt, R.J.; Middleton, B.
    Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria (1992), Biochem. Biophys. Res. Commun., 183, 443 - 448.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.211 47000
-
 alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE Homo sapiens
1.1.1.211 71000
-
 alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE Homo sapiens
1.1.1.211 230000
-
 liver, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.211 additional information Homo sapiens trifunctional, membrane bound, beta-oxidation enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.211 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.211
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.211 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.211 additional information
-
 no activity with acetoacetyl-CoA Homo sapiens
1.1.1.211 3.2 7.4 3-hydroxyoctanoyl-CoA oxidation Homo sapiens
1.1.1.211 15 35 3-ketohexadecanoyl-CoA reduction Homo sapiens
1.1.1.211 16.3
-
 3-ketohexadecanoyl-CoA reduction Homo sapiens
1.1.1.211 30.4
-
 3-ketohexadecanoyl-CoA reduction Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.211 3-hydroxyoctanoyl-CoA + NAD+
-
 Homo sapiens 3-ketooctanoyl-CoA + NADH
-
 ?
1.1.1.211 3-ketohexadecanoyl-CoA + NADH
-
 Homo sapiens 3-hydroxyhexadecanoyl-CoA + NAD+
-
 ?
1.1.1.211 3-ketohexanoyl-CoA + NADH
-
 Homo sapiens 3-hydroxyhexanoyl-CoA + NAD+
-
 ?
1.1.1.211 3-oxodecanoyl-CoA + NADH
-
 Homo sapiens 3-hydroxydecanoyl-CoA + NAD+
-
 ?
1.1.1.211 additional information trifunctional, membrane bound, beta-oxidation enzyme Homo sapiens ?
-
 ?
1.1.1.211 additional information has also enoyl-CoA-hydratase activity Homo sapiens additional information has also 3-ketoacyl-CoA thiolase activity ?

Subunits

EC Number Subunits Comment Organism
1.1.1.211 tetramer alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.211 NAD+
-
 Homo sapiens
1.1.1.211 NADH
-
 Homo sapiens