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Literature summary extracted from

  • Fujimoto, K.; Hara, M.; Yamada, H.; Sakurai, M.; Inaba, A.; Tomomura, A.; Katoh, S.
    Role of the conserved Ser-Tyr-Lys triad of the SDR family in sepiapterin reductase (2001), Chem. Biol. Interact., 130-132, 825-832.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.153 site-directed mutagenesis, recombinant protein expressed in Escherichia coli GI724 Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.153 K175I decreased activity against a pteridine substrate and exogenous carbonyl compound Rattus norvegicus
1.1.1.153 S158D decreased activity against a pteridine substrate and exogenous carbonyl compound Rattus norvegicus
1.1.1.153 S158D/Y171V double-point mutant does not show any activity towards any substrate Rattus norvegicus
1.1.1.153 Y171V decreased activity against a pteridine substrate and exogenous carbonyl compound Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus
-
 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 1-phenyl-1,2-propanedione + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
 Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
1.1.1.153 6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
-
 Rattus norvegicus L-erythro-tetrahydrobiopterin + 2 NADP+
-
 ?
1.1.1.153 acetohexamide + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 menadione + NADPH
-
 Rattus norvegicus ?
-
 ?
1.1.1.153 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzyl alcohol + NADP+
-
 ?
1.1.1.153 propiophenone + NADPH
-
 Rattus norvegicus ?
-
 ?