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Literature summary extracted from

  • Okita, R.T.; Okita, J.R.
    Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD+-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase (1996), CRC Crit. Rev. Biochem., 31, 101-126.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 2-hydroxy-5-(3,5-dimethoxycarbonyl-benzoyl)-benzene acetic acid 1000 times more potent inhibitor than sulfaphasalazine Bos taurus
1.1.1.141 2-hydroxy-5-(3,5-dimethoxycarbonyl-benzoyl)-benzene acetic acid 1000 times more potent inhibitor than sulfaphasalazine Homo sapiens
1.1.1.141 acrolein irreversible inhibition Sus scrofa
1.1.1.141 ethanol
-
 Homo sapiens
1.1.1.141 ethanol
-
 Rattus norvegicus
1.1.1.141 additional information not inhibitited by iodoacetimide Homo sapiens
1.1.1.141 N-Chlorosuccinimide
-
 Sus scrofa
1.1.1.141 pyridoxal 5'-phosphate
-
 Homo sapiens
1.1.1.141 sulphasalazine anticolitic drug Bos taurus
1.1.1.141 sulphasalazine anticolitic drug Homo sapiens
1.1.1.141 Tetranitromethane
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.141 0.012
-
 (5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid
-
 Oryctolagus cuniculus
1.1.1.141 0.016
-
 15-hydroxyeicosatetraenoic acid
-
 Oryctolagus cuniculus
1.1.1.141 0.033
-
 prostaglandin E1
-
 Oryctolagus cuniculus
1.1.1.141 0.038
-
 prostaglandin A1
-
 Oryctolagus cuniculus
1.1.1.141 0.059
-
 prostaglandin E2
-
 Oryctolagus cuniculus
1.1.1.141 0.077
-
 19-hydroxyprostaglandin E1
-
 Oryctolagus cuniculus
1.1.1.141 0.077
-
 prostaglandin E3
-
 Oryctolagus cuniculus
1.1.1.141 0.133
-
 prostaglandin F2alpha
-
 Oryctolagus cuniculus
1.1.1.141 0.283
-
 20-hydroxyprostaglandin E1
-
 Oryctolagus cuniculus
1.1.1.141 0.741
-
 Prostaglandin D2
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.184 13,14-dihydro-15-ketoprostaglandin F2alpha + NADPH Rattus norvegicus
-
 13,14-dihydroprostaglandin F2alpha + NADP+
-
 ?
1.1.1.184 13,14-dihydro-15-ketoprostaglandin F2alpha + NADPH Oryctolagus cuniculus
-
 13,14-dihydroprostaglandin F2alpha + NADP+
-
 ?
1.1.1.184 prostaglandin E2 + NADPH Rattus norvegicus
-
 prostaglandin F2alpha + NADP+
-
 ?
1.1.1.184 prostaglandin E2 + NADPH Oryctolagus cuniculus
-
 prostaglandin F2alpha + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Bos taurus
-
-
-
1.1.1.141 Homo sapiens
-
-
-
1.1.1.141 Oryctolagus cuniculus
-
-
-
1.1.1.141 Rattus norvegicus
-
-
-
1.1.1.141 Sus scrofa
-
-
-
1.1.1.184 Oryctolagus cuniculus
-
-
-
1.1.1.184 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.184 ovary
-
 Rattus norvegicus
-
1.1.1.184 ovary
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.141 additional information
-
 6.1 pmol/min per 1000000 cells, enzyme activity in LNCaP cells Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Oryctolagus cuniculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 (5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+
-
 Homo sapiens (5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH
-
 ?
1.1.1.141 (5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+
-
 Oryctolagus cuniculus (5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Homo sapiens 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Sus scrofa 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Bos taurus 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Oryctolagus cuniculus 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 15-hydroxyeicosatetraenoic acid + NAD+
-
 Oryctolagus cuniculus 15-ketoeicosatetraenoic acid + NADH
-
 ?
1.1.1.141 19-hydroxyprostaglandin E1 + NAD+
-
 Oryctolagus cuniculus 19-hydroxy-15-oxoprostaglandin E1 + NADH
-
 ?
1.1.1.141 20-hydroxyprostaglandin E1 + NAD+
-
 Oryctolagus cuniculus 20-hydroxy-15-ketoprostaglandin E1 + NADH
-
 ?
1.1.1.141 prostaglandin A1 + NAD+
-
 Homo sapiens 15-ketoprostaglandin A1 + NADH + H+
-
 ?
1.1.1.141 prostaglandin A1 + NAD+
-
 Oryctolagus cuniculus 15-ketoprostaglandin A1 + NADH + H+
-
 ?
1.1.1.141 prostaglandin D2 + NAD+
-
 Oryctolagus cuniculus 15-ketoprostaglandin D2 + NADH + H+
-
 ?
1.1.1.141 prostaglandin E1 + NAD+
-
 Oryctolagus cuniculus ? + NADH
-
 ?
1.1.1.141 prostaglandin E3 + NAD+
-
 Oryctolagus cuniculus 15-keto-prostaglandin E3 + NADH + H+
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+
-
 Homo sapiens 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+
-
 Sus scrofa 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+
-
 Oryctolagus cuniculus 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?
1.1.1.184 13,14-dihydro-15-ketoprostaglandin F2alpha + NADPH
-
 Rattus norvegicus 13,14-dihydroprostaglandin F2alpha + NADP+
-
 ?
1.1.1.184 13,14-dihydro-15-ketoprostaglandin F2alpha + NADPH
-
 Oryctolagus cuniculus 13,14-dihydroprostaglandin F2alpha + NADP+
-
 ?
1.1.1.184 prostaglandin E2 + NADPH
-
 Rattus norvegicus prostaglandin F2alpha + NADP+
-
 ?
1.1.1.184 prostaglandin E2 + NADPH
-
 Oryctolagus cuniculus prostaglandin F2alpha + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.184 NADP+
-
 Rattus norvegicus
1.1.1.184 NADP+
-
 Oryctolagus cuniculus