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Literature summary extracted from

  • Hansen, H.S.
    Inhibition by indomethacin and aspirin of 15-hydroxyprostaglandin dehydrogenase in vitro (1974), Prostaglandins, 8, 95-105.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 Acetylsalicylate
-
 Bos taurus
1.1.1.141 indomethacin
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.141 0.0034
-
 prostaglandin E1
-
 Bos taurus
1.1.1.141 0.11
-
 NAD+
-
 Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.141 40000
-
 gel filtration Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.141
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 lung
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.141 0.0014
-
 enzyme from lung Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Bos taurus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
1.1.1.141 prostaglandin E1 + NAD+
-
 Bos taurus 15-oxoprostaglandin E1 + NADH + H+
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.141 0.14
-
 indomethacin
-
 Bos taurus