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Literature summary extracted from

  • Elloumi, N.; Moreau, B.; Aguiar, L.; Jaziri, N.; Sauvage, M.; Hulen, C.; Capmau, M.L.
    Inhibitors of GDP-mannose dehydrogenase of Pseudomonas aeruginosa mucoid strains (1992), Eur. J. Med. Chem., 27, 149-154.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.132 5'-(3-hydroxypropyl)-amino-5'-deoxy-guanosine only after preincubation with enzyme Pseudomonas aeruginosa
1.1.1.132 5'-azido-5'-deoxy-guanosine only after preincubation with enzyme Pseudomonas aeruginosa
1.1.1.132 5'-azido-5'-deoxy-N2-2',3'-O-triacetylguanosine only after preincubation with enzyme Pseudomonas aeruginosa
1.1.1.132 5'[[[[(2'',3'',4'',6''-tetra-O-acetyl 6''-ethynyl)alpha-D-mannopyranosyl oxy]-carbonyl]amino]sulfonyl]-2',3'-isopropylidene N2-acetyl guanosine GDP-analog, 0.1 mM, 60% inhibition Pseudomonas aeruginosa
1.1.1.132 guanosine slight inhibition only after preincubation with enzyme Pseudomonas aeruginosa
1.1.1.132 additional information strains which resist 0.005 mg/ml of tobramycin treated by 5'-(3-hydroxypropyl)-amino-5'-deoxy-guanosine, tetra-O-acetylmannopyranose and 5'[[[[(2'',3'',4'',6''-tetra-O-acetyl 6''-ethynyl)alpha-D-mannopyranosyl oxy]-carbonyl]amino]sulfonyl]-2',3'-isopropylidene N2-acetyl guanosine recover 20, 75 and 85% of their sensisivity towards tobramycin Pseudomonas aeruginosa
1.1.1.132 N2-acetyl-2',3'-isopropylidene guanosine only after preincubation with enzyme Pseudomonas aeruginosa
1.1.1.132 N2-acetyl-5'-amino-5'-deoxy-2',3'-O-acetylguanosine only after preincubation with enzyme Pseudomonas aeruginosa
1.1.1.132 N2-acetyl-5'-amino-5'-deoxy-guanosine only after preincubation with enzyme Pseudomonas aeruginosa
1.1.1.132 N2-acetyl-guanosine only after preincubation with enzyme Pseudomonas aeruginosa
1.1.1.132 tetra-O-acetylmannopyranose GDP-analog, 0.1 mM, 75% inhibition Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.132 Pseudomonas aeruginosa
-
 A22 alg+, selected from mucoid strain IPA22
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.132 protamine sulfate precipitation, gel exclusion, ion exchange chromatography Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.132 GDP-mannose + NAD+ + H2O
-
 Pseudomonas aeruginosa GDP-mannuronate + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.132 NAD+
-
 Pseudomonas aeruginosa