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Literature summary extracted from
- Characterization of Coturnix quail liver alcohol dehydrogenase enzymes (1989), Biochemistry, 28, 6245-6251.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | pyrazole | pyrazole-sensitive enzyme forms ADH-1, ADH-2, ADH-3 and the pyrazole-insensitive form ADH-An | Coturnix coturnix |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.1 | 0.0051 | - |
NADH | reduction of octanal | Coturnix coturnix | |
| 1.1.1.1 | 0.011 | - |
octan-1-ol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 0.013 | - |
benzyl alcohol | enzyme form ADH-2 | Coturnix coturnix | |
| 1.1.1.1 | 0.04 | - |
12-hydroxydodecanoate | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 0.043 | - |
octanal | enzyme form ADH-2 | Coturnix coturnix | |
| 1.1.1.1 | 0.2 | - |
pentan-1-ol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 0.23 | - |
NAD+ | oxidation of ethanol | Coturnix coturnix | |
| 1.1.1.1 | 2 | - |
butan-1-ol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 5.2 | - |
Cyclohexanol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 8.1 | - |
ethanol | enzyme form ADH-3 | Coturnix coturnix | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.1 | 42000 | - |
2 * 42000, enzyme form ADH-2 and ADH-3, SDS-PAGE | Coturnix coturnix |
| 1.1.1.1 | 82750 | - |
enzyme form ADH-3, equilibrium sedimentation | Coturnix coturnix |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | Coturnix coturnix | - |
japonica. ADH-1, ADH-2, ADH-3 and ADH-An | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.1 | ADH-2 and ADH-3 | Coturnix coturnix |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | liver | - |
Coturnix coturnix | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.1 | 12-hydroxydodecanoate + NAD+ | - |
Coturnix coturnix | 12-oxododecanoic acid + NADH | - |
? | |
| 1.1.1.1 | benzyl alcohol + NAD+ | - |
Coturnix coturnix | benzaldehyde + NADH | - |
? | |
| 1.1.1.1 | butanol + NAD+ | - |
Coturnix coturnix | butyraldehyde + NADH | - |
? | |
| 1.1.1.1 | cyclohexanol + NAD+ | - |
Coturnix coturnix | cyclohexanone + NADH | - |
? | |
| 1.1.1.1 | ethanol + NAD+ | - |
Coturnix coturnix | acetaldehyde + NADH | - |
? | |
| 1.1.1.1 | ethylene glycol + NAD+ | no activity | Coturnix coturnix | ? + NADH | - |
? | |
| 1.1.1.1 | methanol + NAD+ | no activity | Coturnix coturnix | formaldehyde + NADH + H+ | - |
? | |
| 1.1.1.1 | octan-1-ol + NAD+ | - |
Coturnix coturnix | n-octanal + NADH | - |
? | |
| 1.1.1.1 | octanal + NADH + H+ | - |
Coturnix coturnix | octanol + NAD+ | - |
? | |
| 1.1.1.1 | pentanol + NAD+ | - |
Coturnix coturnix | n-pentanal + NADH | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.1 | dimer | 2 * 42000, enzyme form ADH-2 and ADH-3, SDS-PAGE | Coturnix coturnix |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.1 | 0.75 | - |
Cyclohexanol | enzyme form ADH-2 | Coturnix coturnix | |
| 1.1.1.1 | 1.45 | - |
12-hydroxydodecanoate | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 1.85 | - |
octan-1-ol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 2.52 | - |
benzyl alcohol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 2.92 | - |
pentan-1-ol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 3.55 | - |
Cyclohexanol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 4.67 | - |
NAD+ | enzyme form ADH-2 | Coturnix coturnix | |
| 1.1.1.1 | 4.92 | - |
ethanol | enzyme form ADH-2 | Coturnix coturnix | |
| 1.1.1.1 | 6.18 | - |
NAD+ | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 6.63 | - |
ethanol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 7.22 | - |
butan-1-ol | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 8.88 | - |
NADH | enzyme form ADH-3 | Coturnix coturnix | |
| 1.1.1.1 | 17 | - |
octanal | enzyme form ADH-3 | Coturnix coturnix | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.1 | 6.5 | - |
reduction of octanal | Coturnix coturnix |
| 1.1.1.1 | 11 | - |
ethanol oxidation, enzyme form ADH-2 and ADH-3 | Coturnix coturnix |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.1 | 9.5 | 11.5 | pH 9.5: about 40% of maximal activity, pH 11.5: about 85% of maximal activity, ethanol oxidation enzyme form ADH-3 | Coturnix coturnix |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | NAD+ | - |
Coturnix coturnix | |
| 1.1.1.1 | NADH | - |
Coturnix coturnix | |
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