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Literature summary extracted from
- Separation and partial characterization of multiple forms of rat liver alcohol dehydrogenase (1983), Arch. Biochem. Biophys., 225, 787-794.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | 4-methoxypyrazole | competitive inhibitor of all four isoenzymes | Rattus norvegicus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.1 | 0.021 | - |
5alpha-androstan-17beta-ol-3-one | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.025 | - |
5alpha-androstan-17beta-ol-3-one | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.027 | - |
5alpha-androstan-17beta-ol-3-one | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 0.032 | - |
3beta-7alpha-dihydroxy-5beta-cholanoate | isoenzyme 3 | Rattus norvegicus | |
| 1.1.1.1 | 0.04 | - |
5alpha-androstan-17beta-ol-3-one | isoenzyme 1 | Rattus norvegicus | |
| 1.1.1.1 | 0.044 | - |
NAD+ | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 0.051 | - |
NADH | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 0.057 | - |
NAD+ | isoenzyme 1 | Rattus norvegicus | |
| 1.1.1.1 | 0.064 | - |
3beta-7alpha-dihydroxy-5beta-cholanoate | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.066 | - |
3beta-7alpha-dihydroxy-5beta-cholanoate | isoenzyme 1 | Rattus norvegicus | |
| 1.1.1.1 | 0.071 | - |
NADH | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.071 | - |
3beta-7alpha-dihydroxy-5beta-cholanoate | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 0.076 | - |
NADH | isoenzyme 1 | Rattus norvegicus | |
| 1.1.1.1 | 0.091 | - |
NADH | isoenzyme 3 | Rattus norvegicus | |
| 1.1.1.1 | 0.099 | - |
NAD+ | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.115 | - |
NAD+ | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.123 | - |
5beta-androstan-3beta-ol-17 one | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 0.125 | - |
5beta-androstan-3beta-ol-17 one | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.128 | - |
3beta,12alpha-dihydroxy-5beta-cholanoate | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.14 | - |
5beta-androstan-3beta-ol-17 one | isoenzyme 3 | Rattus norvegicus | |
| 1.1.1.1 | 0.149 | - |
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate | isoenzyme I | Rattus norvegicus | |
| 1.1.1.1 | 0.16 | - |
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.16 | - |
3beta,12alpha-dihydroxy-5beta-cholanoate | isoenzyme 3 | Rattus norvegicus | |
| 1.1.1.1 | 0.164 | - |
5beta-androstan-3beta-ol-17 one | isoenzyme 1 | Rattus norvegicus | |
| 1.1.1.1 | 0.182 | - |
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate | isoenzyme 3 | Rattus norvegicus | |
| 1.1.1.1 | 0.217 | - |
acetaldehyde | isoenzyme 3 | Rattus norvegicus | |
| 1.1.1.1 | 0.23 | - |
acetaldehyde | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 0.248 | - |
3beta,12alpha-dihydroxy-5beta-cholanoate | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 0.276 | - |
acetaldehyde | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 0.31 | - |
acetaldehyde | isoenzyme 1 | Rattus norvegicus | |
| 1.1.1.1 | 0.31 | - |
3beta,12alpha-dihydroxy-5beta-cholanoate | isoenzyme I | Rattus norvegicus | |
| 1.1.1.1 | 0.35 | - |
3beta,7alpha-12alpha-trihydroxy-5beta-cholanoate | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 0.76 | - |
ethanol | isoenzyme 2 | Rattus norvegicus | |
| 1.1.1.1 | 1.37 | - |
ethanol | isoenzyme 1 | Rattus norvegicus | |
| 1.1.1.1 | 1.41 | - |
ethanol | isoenzyme 4 | Rattus norvegicus | |
| 1.1.1.1 | 1.87 | - |
ethanol | isoenzyme 3 | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | Rattus norvegicus | - |
isoenzyme 1, 2, 3 and 4 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.1 | isoenzyme 1, 2, 3, and 4 | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.1 | 3beta,12alpha-dihydroxy-5beta-cholanoic acid + NAD+ | - |
Rattus norvegicus | ? + NADH | - |
? | |
| 1.1.1.1 | 3beta,7alpha,12alpha-trihydroxy-5beta-cholanoic acid + NAD+ | - |
Rattus norvegicus | ? + NADH | - |
? | |
| 1.1.1.1 | 3beta,7alpha-dihydroxy-5beta-cholanoic acid + NAD+ | - |
Rattus norvegicus | ? + NADH | - |
? | |
| 1.1.1.1 | 3beta-7alpha-dihydroxy-5beta-cholanoate + NAD+ | - |
Rattus norvegicus | 17-hydroxy-3-oxo-5beta-cholanoate + NADH + H+ | - |
r | |
| 1.1.1.1 | 3beta-hydroxy-5beta-androstan-17-one + NAD+ | - |
Rattus norvegicus | 5beta-androstan-3,17-dione + NADH | - |
? | |
| 1.1.1.1 | 5alpha-androstan-17beta-ol-3-one + NADH + H+ | - |
Rattus norvegicus | 3beta,17beta-dihydroxy-5alpha-androstan + NAD+ | - |
? | |
| 1.1.1.1 | acetaldehyde + NADH + H+ | - |
Rattus norvegicus | ethanol + NAD+ | - |
r | |
| 1.1.1.1 | ethanol + NAD+ | - |
Rattus norvegicus | acetaldehyde + NADH | - |
r | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.1 | 9.5 | - |
oxidation of ethanol | Rattus norvegicus |
| 1.1.1.1 | 9.5 | - |
isoenzyme 1 | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | NAD+ | - |
Rattus norvegicus | |
| 1.1.1.1 | NADH | - |
Rattus norvegicus | |
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