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Literature summary extracted from

  • Cooper, D.Y.; Schleyer, H.; Levin, S.S.; Rosenthal, O.
    Studies on the partially purified heme protein P-450 from the adrenal cortex (1973), Ann. N. Y. Acad. Sci., 212, 227-242.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.4 iron-sulfur protein adrenodoxin, at high concentrations, 25% inhibition Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.4 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.4 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.15.4 sonication, acetone and butanol extraction, Triton extraction Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.15.4 a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O 2 step reduction: reduction of P-450 with non-specific donor and reduction which is specifically dependent on reduced iron-sulfur protein Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.4 adrenal cortex
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.4 11-deoxycorticosterone + reduced adrenal ferredoxin + O2 11beta-hydroxylation Bos taurus corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.4 NADH less effective than NADPH Bos taurus
1.14.15.4 NADPH
-
 Bos taurus