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Literature summary extracted from

  • Palmer, C.N.A.; Richardson, T.H.; Griffin, K.J.; Hsu, M.H.; Muerhoff, A.S.; Clark, J.E.; Johnson, E.F.
    Characterization of a cDNA encoding a human kidney cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli (1993), Biochim. Biophys. Acta, 1172, 161-166.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.15.3 dilauroylphosphatidylcholine needs detergent Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.3 expressed in Escherichia coli , human gene CYP4AII Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.3 arachidonic acid + NADPH + H+ + O2 Homo sapiens
-
 20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
 ?
1.14.15.3 n-alkane + NAD(P)H + H+ + O2 Homo sapiens
-
 n-alkanol + NAD(P)+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.3 renal cortex
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.3 (n-1)-alkanoate + NADPH + H+ + O2
-
 Homo sapiens (omega-1)-hydroxy-n-alkanoate + NADP+ + H2O
-
 ?
1.14.15.3 arachidonic acid + NAD(P)H + H+ + O2
-
 Homo sapiens 20-hydroxyicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
 ?
1.14.15.3 arachidonic acid + NADPH + H+ + O2
-
 Homo sapiens 20-hydroxyeicosatetraenoic acid + NADP+ + H2O
-
 ?
1.14.15.3 fatty acid + NAD(P)H + H+ + O2 pig liver NADPH-P450 reductase and cytochrome b5 are part of the system Homo sapiens omega-hydroxy fatty acid + NAD(P)+ + H2O
-
 ?
1.14.15.3 lauric acid + NAD(P)H + H+ + O2
-
 Homo sapiens 12-hydroxydodecanoic acid + NAD(P)+ + H2O
-
 ?
1.14.15.3 n-alkane + NAD(P)H + H+ + O2
-
 Homo sapiens n-alkanol + NAD(P)+ + H2O
-
 ?
1.14.15.3 palmitic acid + NAD(P)H + H+ + O2
-
 Homo sapiens 16-hydroxyhexadecanoic acid + NAD(P)+ + H2O
-
 ?
1.14.15.3 prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.15.3 37
-
 assay conditions Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.15.3 0.00133
-
 PGA1 omega-hydroxylation Homo sapiens
1.14.15.3 0.0025
-
 arachidonic acid (omega-1)-hydroxylation Homo sapiens
1.14.15.3 0.0085
-
 lauric acid (omega-1)-hydroxylation Homo sapiens
1.14.15.3 0.00917
-
 arachidonic acid omega-hydroxylation Homo sapiens
1.14.15.3 0.0105
-
 palmitic acid (omega-1)-hydroxylation Homo sapiens
1.14.15.3 0.0367
-
 palmitic acid omega-hydroxylation Homo sapiens
1.14.15.3 0.163
-
 lauric acid omega-hydroxylation Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.3 NADPH
-
 Homo sapiens