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Literature summary extracted from
- Cholesterol 7alpha-hydroxylase of rat liver. Studies on the solubilisation, resolution and reconstitution of the enzyme complex (1981), Eur. J. Biochem., 119, 263-272.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.23 | 0.015 | - |
cholesterol | reconstituted enzyme complex | Rattus norvegicus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.23 | microsome | - |
Rattus norvegicus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.23 | Rattus norvegicus | - |
enzyme complex reconstituted from cytochrome P-450 and NADPH-cytochrome P-450 reductase | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.23 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.23 | additional information | specificity of reconstituted enzyme system | Rattus norvegicus | ? | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.23 | NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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