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Literature summary extracted from

  • Verschueren, K.H.G.; Seljee, F.; Rozeboom, H.J.; Kalk, K.H.; Dijkstra, B.W.
    Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase (1993), Nature, 363, 693-698.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.8.1.5
-
 Xanthobacter autotrophicus

Organism

EC Number Organism UniProt Comment Textmining
3.8.1.5 Xanthobacter autotrophicus
-
 GJ10
-
3.8.1.5 Xanthobacter autotrophicus GJ10
-
 GJ10
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.8.1.5 1-haloalkane + H2O = a primary alcohol + halide two-step mechanism involving an ester intermediate covalently bound at Asp124, His 289 is important for hydrolysis Xanthobacter autotrophicus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.8.1.5 1,2-dichloroethane + H2O
-
 Xanthobacter autotrophicus 2-chloroethanol + chloride
-
 ?
3.8.1.5 1,2-dichloroethane + H2O
-
 Xanthobacter autotrophicus GJ10 2-chloroethanol + chloride
-
 ?
3.8.1.5 haloalkane + H2O
-
 Xanthobacter autotrophicus alcohol + halide
-
 ?
3.8.1.5 haloalkane + H2O
-
 Xanthobacter autotrophicus GJ10 alcohol + halide
-
 ?