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Literature summary extracted from

  • Reich-Slotky, R.; Panagiotidis, C.; Reyes, M.; Shuman, H.A.
    The detergent-soluble maltose transporter is activated by maltose binding protein and verapamil (2000), J. Bacteriol., 182, 993-1000.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.5.2.1 maltose-binding protein stimulates detergent-soluble maltose transporter, does not change the affinity of the complex for ATP but does increase the maximal rate of ATP hydrolysis Escherichia coli
7.5.2.1 verapamil stimulates detergent-soluble maltose transporter, increases ATPase activity and lowers affinity for ATP Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.5.2.1 NaN3 FGK2 complex Escherichia coli
7.5.2.1 p-chloromercuriphenyl sulfonic acid FGK2 complex Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.5.2.1 0.143
-
 ATP in presence of 0.05 mM maltose binding protein Escherichia coli
7.5.2.1 0.154
-
 ATP in absence of maltose binding protein Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.5.2.1 cytoplasmic membrane the peripheral membrane protein MalK associates with integral cytoplasmic membrane proteins MalF and MalG to form the maltose transport complex MalFGK Escherichia coli
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.5.2.1 ATP + H2O + maltose/out Escherichia coli the peripheral membrane protein MalK associates with integral cytoplasmic membrane proteins MalF and MalG to form the maltose transport complex MalFGK. In addition malK participates in two different regulatory pathways which modulate mal gene expression and MalFGK transport activity ADP + phosphate + maltose/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.5.2.1 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.5.2.1 with the aid of a glutathione S-transferase molecular tag Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.5.2.1 ATP + H2O + maltose/out
-
 Escherichia coli ADP + phosphate + maltose/in
-
 ?
7.5.2.1 ATP + H2O + maltose/out the peripheral membrane protein MalK associates with integral cytoplasmic membrane proteins MalF and MalG to form the maltose transport complex MalFGK. In addition malK participates in two different regulatory pathways which modulate mal gene expression and MalFGK transport activity Escherichia coli ADP + phosphate + maltose/in
-
 ?