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Literature summary extracted from

  • Beleznay, Z.; Zachowski, A.; Devaux, P.F.; Ott, P.
    Characterization of the correlation between ATP-dependent aminophospholipid translocation and Mg2+-ATPase activity in red blood cell membranes (1997), Eur. J. Biochem., 243, 58-65.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.1 elaiophylin partial inhibition of Mg+-ATPase activity, translocation of phosphatidylserine is almost completely abolished Homo sapiens
7.6.2.1 eosin Y almost complete inhibition of both Mg2+-ATPase activity and translocation Homo sapiens
7.6.2.1 suramin competitive inhibitor of ATP towards both Mg2+-ATPase activity and aminophospholipid translocation. Inhibition of translocation occurs at higher inhibitor concentration than the inhibition of Mg2+-ATPase activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.6.2.1 0.211
-
 ATP phosphatase activity Homo sapiens
7.6.2.1 0.225
-
 ATP phosphatidylserine translocase activity Homo sapiens
7.6.2.1 1.03
-
 acetyl phosphate phosphatase activity Homo sapiens
7.6.2.1 1.17
-
 p-nitrophenyl phosphate phosphatase activity, detection of p-nitrophenolate formation from trichloroacetic acid precipitates Homo sapiens
7.6.2.1 1.31
-
 acetyl phosphate phosphatidylserine translocase activity Homo sapiens
7.6.2.1 1.39
-
 p-nitrophenyl phosphate phosphatidylserine translocase activity Homo sapiens
7.6.2.1 1.46
-
 p-nitrophenyl phosphate phosphatase activity, continous detection of p-nitrophenolate formation in ghost at neutral pH Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.1 plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.6.2.1 Mg2+ required Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.1 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
7.6.2.1 ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2] P-type ATPase Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.1 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.1 acetyl phosphate + H2O translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts Homo sapiens acetate + phosphate
-
 ?
7.6.2.1 ATP + H2O translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts Homo sapiens ADP + phosphate
-
 ?
7.6.2.1 p-nitrophenyl phosphate + H2O translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts Homo sapiens p-nitrophenol + phosphate
-
 ?