BRENDA - Enzyme Database

Phosphonate analogues of diadenosine 5,5-P1,P4-tetraphosphate as substrates or inhibitors of procaryotic and eucaryotic enzymes degrading dinucleoside tetraphosphates

Guranowski, A.; Biryukov, A.; Tarussova, N.B.; Khomutov, R.M.; Jakubowski, H.; Biochemistry 26, 3425-3429 (1987)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.41
Ap(CH2)pp(CH2)pA
-
Escherichia coli
3.6.1.41
App(CH2)ppA
-
Escherichia coli
3.6.1.41
App(CHBr)ppA
-
Escherichia coli
3.6.1.41
Appp(CH2)pA
-
Escherichia coli
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.7.53
additional information
-
additional information
-
Saccharomyces cerevisiae
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.7.53
Saccharomyces cerevisiae
-
-
-
3.6.1.41
Escherichia coli
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.53
additional information
no substrates are phosphonate analogs of Ap4A
246767
Saccharomyces cerevisiae
?
-
-
-
-
2.7.7.53
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
i.e. Ap4A or AppppA, substrate specificity
246767
Saccharomyces cerevisiae
ADP + ATP
-
246767
Saccharomyces cerevisiae
r
2.7.7.53
P1,P4-bis(5'-adenosyl) tetraphosphate with CH2-bridge between P3 and P4 + phosphate
i.e. ApppCH2pA, methylene group substituting the oxygen
246767
Saccharomyces cerevisiae
?
-
-
-
?
3.6.1.41
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
246767
Escherichia coli
ADP
-
246767
Escherichia coli
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.7.7.53
additional information
-
additional information
-
Saccharomyces cerevisiae
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.41
Ap(CH2)pp(CH2)pA
-
Escherichia coli
3.6.1.41
App(CH2)ppA
-
Escherichia coli
3.6.1.41
App(CHBr)ppA
-
Escherichia coli
3.6.1.41
Appp(CH2)pA
-
Escherichia coli
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.7.7.53
additional information
-
additional information
-
Saccharomyces cerevisiae
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.7.53
additional information
-
additional information
-
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.53
additional information
no substrates are phosphonate analogs of Ap4A
246767
Saccharomyces cerevisiae
?
-
-
-
-
2.7.7.53
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
i.e. Ap4A or AppppA, substrate specificity
246767
Saccharomyces cerevisiae
ADP + ATP
-
246767
Saccharomyces cerevisiae
r
2.7.7.53
P1,P4-bis(5'-adenosyl) tetraphosphate with CH2-bridge between P3 and P4 + phosphate
i.e. ApppCH2pA, methylene group substituting the oxygen
246767
Saccharomyces cerevisiae
?
-
-
-
?
3.6.1.41
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
246767
Escherichia coli
ADP
-
246767
Escherichia coli
?