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Literature summary extracted from
- Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase (1992), Biochem. Pharmacol., 43, 1295-1301.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.2.3 | 5-aminoorotate | - |
Plasmodium berghei |  |
| 3.5.2.3 | 5-bromoorotate | - |
Plasmodium berghei | |
| 3.5.2.3 | 5-Fluoroorotate | - |
Plasmodium berghei | |
| 3.5.2.3 | 5-iodoorotate | - |
Plasmodium berghei | |
| 3.5.2.3 | 5-Methylorotate | - |
Plasmodium berghei | |
| 3.5.2.3 | Orotate | - |
Plasmodium berghei | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.2.3 | 0.008 | - |
L-dihydroorotate | - |
Plasmodium berghei | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.2.3 | Plasmodium berghei | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.2.3 | - |
Plasmodium berghei |
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