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Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA

Frothingham, R.; Meeker-OƦConnell, W.A.; Talbot, E.A.S.; George, J.W.; Kreuzer K.N.; Antimicrob. Agents Chemother. 40, 1426-1431 (1996)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.5.1.19
a single enzyme accounts for both pyrazinamidase activity and nicotinamidase activity
Escherichia coli
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.1.19
Escherichia coli
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.1.19
nicotinamide + H2O
-
246582
Escherichia coli
nicotinate + NH3
-
-
-
?
3.5.1.19
pyrazinamide + H2O
-
246582
Escherichia coli
pyrazinoic acid + NH3
-
246582
Escherichia coli
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.5.1.19
a single enzyme accounts for both pyrazinamidase activity and nicotinamidase activity
Escherichia coli
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.1.19
nicotinamide + H2O
-
246582
Escherichia coli
nicotinate + NH3
-
-
-
?
3.5.1.19
pyrazinamide + H2O
-
246582
Escherichia coli
pyrazinoic acid + NH3
-
246582
Escherichia coli
?