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Literature summary extracted from

  • Grabowski, R.; Hofmeister, A.E.M.; Buckel, W.
    Bacterial L-serine dehydratases: a new family of enzymes containing iron-sulfur clusters (1993), Trends Biochem. Sci., 18, 297-300.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.3.1.17 Fe2+ required Clostridium acidi-urici
4.3.1.17 Fe2+ required Limosilactobacillus fermentum
4.3.1.17 Fe2+ requires activation Escherichia coli
4.3.1.17 Iron enzyme contains one [4Fe-4S]cluster per heterodimer Peptoniphilus asaccharolyticus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.17 25000
-
 1 * 25000 + 1 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 25000
-
 2 * 25000 + 2 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 25000
-
 3 * 25000 + 3 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 25000
-
 4 * 25000 + 4 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 30000
-
 1 * 25000 + 1 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 30000
-
 2 * 25000 + 2 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 30000
-
 3 * 25000 + 3 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 30000
-
 4 * 25000 + 4 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.17 Arthrobacter globiformis
-
-
-
4.3.1.17 Burkholderia cepacia
-
-
-
4.3.1.17 Clostridium acidi-urici
-
-
-
4.3.1.17 Escherichia coli
-
-
-
4.3.1.17 Klebsiella aerogenes
-
-
-
4.3.1.17 Limosilactobacillus fermentum
-
-
-
4.3.1.17 Peptoniphilus asaccharolyticus
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
4.3.1.17 inactivated upon exposure to air, reactivated by Fe2+ under aerobic conditions Peptoniphilus asaccharolyticus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.17 L-serine
-
 Escherichia coli pyruvate + NH3
-
 ?
4.3.1.17 L-serine
-
 Klebsiella aerogenes pyruvate + NH3
-
 ?
4.3.1.17 L-serine
-
 Clostridium acidi-urici pyruvate + NH3
-
 ?
4.3.1.17 L-serine
-
 Peptoniphilus asaccharolyticus pyruvate + NH3
-
 ?
4.3.1.17 L-serine
-
 Arthrobacter globiformis pyruvate + NH3
-
 ?
4.3.1.17 L-serine
-
 Limosilactobacillus fermentum pyruvate + NH3
-
 ?
4.3.1.17 L-serine
-
 Burkholderia cepacia pyruvate + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
4.3.1.17 dimer 1 * 25000 + 1 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 hexamer 3 * 25000 + 3 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 octamer 4 * 25000 + 4 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus
4.3.1.17 tetramer
-
 Limosilactobacillus fermentum
4.3.1.17 tetramer 2 * 25000 + 2 * 30000, the enzyme is composed of two different subunits in a 1:1 stoichiometry, forming heterodimers to heterooctamers Peptoniphilus asaccharolyticus

Cofactor

EC Number Cofactor Comment Organism Structure
4.3.1.17 pyridoxal 5'-phosphate pyridoxal-5'-phosphate-independent enzyme Klebsiella aerogenes
4.3.1.17 pyridoxal 5'-phosphate pyridoxal-5'-phosphate-independent enzyme Peptoniphilus asaccharolyticus
4.3.1.17 pyridoxal 5'-phosphate pyridoxal-5'-phosphate-independent enzyme Limosilactobacillus fermentum
4.3.1.17 pyridoxal 5'-phosphate pyridoxal-5'-phosphate-independent enzyme Burkholderia cepacia