BRENDA - Enzyme Database show

240-kDa proteasome inhibitor (CF-2) is identical to delta-aminolevulinic acid dehydratase

Guo, G.G.; Gu, M.; Etlinger, J.D.; J. Biol. Chem. 269, 12399-12402 (1994)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.24
5-aminolevulinate
Homo sapiens
second enzyme in the heme biosynthetic pathway
?
-
-
-
4.2.1.24
additional information
Homo sapiens
the enzyme has a dual role: 1. as 5-aminolevulinate dehydatase, the second enzyme in the pathway of heme synthesis, 2. as CF-2 proteasome inhibitor
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.24
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate
second enzyme in the heme biosynthetic pathway
210724
Homo sapiens
?
-
-
-
-
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
210724
Homo sapiens
porphobilinogen + 2 H2O
-
210724
Homo sapiens
?
4.2.1.24
additional information
the enzyme has a dual role: 1. as 5-aminolevulinate dehydatase, the second enzyme in the pathway of heme synthesis, 2. as CF-2 proteasome inhibitor
210724
Homo sapiens
?
-
-
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.24
5-aminolevulinate
Homo sapiens
second enzyme in the heme biosynthetic pathway
?
-
-
-
4.2.1.24
additional information
Homo sapiens
the enzyme has a dual role: 1. as 5-aminolevulinate dehydatase, the second enzyme in the pathway of heme synthesis, 2. as CF-2 proteasome inhibitor
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate
second enzyme in the heme biosynthetic pathway
210724
Homo sapiens
?
-
-
-
-
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
210724
Homo sapiens
porphobilinogen + 2 H2O
-
210724
Homo sapiens
?
4.2.1.24
additional information
the enzyme has a dual role: 1. as 5-aminolevulinate dehydatase, the second enzyme in the pathway of heme synthesis, 2. as CF-2 proteasome inhibitor
210724
Homo sapiens
?
-
-
-
-