BRENDA - Enzyme Database show

Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity

Bevan, D.R.; Bodlaender, P.; Shemin, D.; J. Biol. Chem. 255, 2030-2035 (1980)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
1,10-phenanthroline
-
Bos taurus
4.2.1.24
8-Hydroxyquinoline-5-sulfonic acid
-
Bos taurus
4.2.1.24
bathocuproine disulfonic acid
-
Bos taurus
4.2.1.24
EDTA
-
Bos taurus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
4.2.1.24
Cd2+
can restore activity of the apoenzyme
Bos taurus
4.2.1.24
Zn2+
Zn2+ forms a bond with a sulfhydryl group in the enzyme, the octameric enzyme contains 4 gatom of Zn2+ per mol of enzyme, Zn2+ does not participate in substrate binding nor in the maintenance of the quarternary structure of the enzyme
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.24
Bos taurus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.24
liver
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
210696
Bos taurus
porphobilinogen + 2 H2O
-
210696
Bos taurus
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.24
1,10-phenanthroline
-
Bos taurus
4.2.1.24
8-Hydroxyquinoline-5-sulfonic acid
-
Bos taurus
4.2.1.24
bathocuproine disulfonic acid
-
Bos taurus
4.2.1.24
EDTA
-
Bos taurus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
4.2.1.24
Cd2+
can restore activity of the apoenzyme
Bos taurus
4.2.1.24
Zn2+
Zn2+ forms a bond with a sulfhydryl group in the enzyme, the octameric enzyme contains 4 gatom of Zn2+ per mol of enzyme, Zn2+ does not participate in substrate binding nor in the maintenance of the quarternary structure of the enzyme
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.24
liver
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
210696
Bos taurus
porphobilinogen + 2 H2O
-
210696
Bos taurus
?