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Literature summary extracted from

  • Rivett, A.J.; Mason, G.G.F.; Murray, R.Z.; Reidlinger, J.
    Regulation of proteasome structure and function (1997), Mol. Biol. Rep., 24, 99-102.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.1.5 24000
-
 recombinant subunit, expressed in E. coli, 2D-PAGE Rattus norvegicus
5.6.1.5 700000
-
-
 Rattus norvegicus
5.6.1.5 700000
-
 proteasome, multicatalytic proteinase complex, central catalytic core Saccharomyces cerevisiae
5.6.1.5 700000
-
 proteasome, multicatalytic proteinase complex, central catalytic core Thermoplasma sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide Rattus norvegicus
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Saccharomyces cerevisiae
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Thermoplasma sp.
-
 ADP + phosphate + unfolded polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.5 Rattus norvegicus
-
 rat
-
5.6.1.5 Saccharomyces cerevisiae
-
-
-
5.6.1.5 Thermoplasma sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.5 26S proteinase Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Rattus norvegicus
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Saccharomyces cerevisiae
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Thermoplasma sp.
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.5 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide
-
 Rattus norvegicus ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Saccharomyces cerevisiae ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Thermoplasma sp. ADP + phosphate + unfolded polypeptide
-
 ?