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Literature summary extracted from
- Reconstitution of membrane transport powered by a novel dimeric kinesin motor of the Unc104/KIF1A family purified from Dictyostelium (1999), J. Cell Biol., 147, 493-506.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.6.1.3 | cloning of the DdUnc104 gene, also known as ksnA gene, by PCR amplified cDNA | Dictyostelium discoideum |
| 5.6.1.3 | partial clone of TLKIF1 cloned | Thermomyces lanuginosus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.6.1.3 | cytoplasm | - |
Mus musculus | 5737 | - |
| 5.6.1.3 | cytoplasm | - |
Dictyostelium discoideum | 5737 | - |
| 5.6.1.3 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| 5.6.1.3 | endoplasmic reticulum | - |
Dictyostelium discoideum | 5783 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.6.1.3 | 170000 | - |
gel filtration | Dictyostelium discoideum |
| 5.6.1.3 | 245000 | - |
gel filtration | Dictyostelium discoideum |
| 5.6.1.3 | 248000 | - |
2 * 248000, Ddunc104, SDS-PAGE | Dictyostelium discoideum |
| 5.6.1.3 | 480000 | - |
calculated from Stokes' radius | Dictyostelium discoideum |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n | Mus musculus | - |
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |  |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n | Dictyostelium discoideum | - |
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n | Caenorhabditis elegans | - |
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n | Thermomyces lanuginosus | - |
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | GTP + H2O + a kinesin associated with a microtubule at position n | Mus musculus | - |
GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | GTP + H2O + a kinesin associated with a microtubule at position n | Dictyostelium discoideum | - |
GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | GTP + H2O + a kinesin associated with a microtubule at position n | Caenorhabditis elegans | - |
GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | GTP + H2O + a kinesin associated with a microtubule at position n | Thermomyces lanuginosus | - |
GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.1.3 | Caenorhabditis elegans | - |
- |
- |
| 5.6.1.3 | Dictyostelium discoideum | - |
- |
- |
| 5.6.1.3 | Mus musculus | - |
- |
- |
| 5.6.1.3 | Thermomyces lanuginosus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.6.1.3 | - |
Dictyostelium discoideum |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. | Mus musculus | |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. | Dictyostelium discoideum | |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. | Caenorhabditis elegans | |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. | Thermomyces lanuginosus |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.6.1.3 | 11.67 | - |
- |
Dictyostelium discoideum |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n | - |
Mus musculus | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n | - |
Dictyostelium discoideum | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n | - |
Caenorhabditis elegans | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | ATP + H2O + a kinesin associated with a microtubule at position n | - |
Thermomyces lanuginosus | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | GTP + H2O + a kinesin associated with a microtubule at position n | - |
Mus musculus | GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | GTP + H2O + a kinesin associated with a microtubule at position n | - |
Dictyostelium discoideum | GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | GTP + H2O + a kinesin associated with a microtubule at position n | - |
Caenorhabditis elegans | GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| 5.6.1.3 | GTP + H2O + a kinesin associated with a microtubule at position n | - |
Thermomyces lanuginosus | GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.6.1.3 | dimer | - |
Mus musculus |
| 5.6.1.3 | dimer | 2 * 248000, Ddunc104, SDS-PAGE | Dictyostelium discoideum |
| 5.6.1.3 | monomer | Unc104 | Caenorhabditis elegans |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.6.1.3 | DdUnc104 | - |
Dictyostelium discoideum |
| 5.6.1.3 | KIF1A | - |
Mus musculus |
| 5.6.1.3 | TLKIF1 | - |
Thermomyces lanuginosus |
| 5.6.1.3 | Unc104 | - |
Caenorhabditis elegans |
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