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Literature summary extracted from

  • Bellamy, W.T.
    P-glycoproteins and multidrug resistance (1996), Annu. Rev. Pharmacol. Toxicol., 36, 161-183.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2 expression in Xenopus oocytes Mus musculus
7.6.2.2 expression in Xenopus oocytes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
 Mus musculus 16020
-
7.6.2.2 membrane
-
 Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.6.2.2 120000 140000 P-glycoprotein Homo sapiens
7.6.2.2 190000
-
 1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 additional information Mus musculus energy-dependent drug efflux pump ?
-
 ?
7.6.2.2 additional information Homo sapiens energy-dependent drug efflux pump ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Cricetinae
-
-
-
7.6.2.2 Homo sapiens
-
-
-
7.6.2.2 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.6.2.2 glycoprotein one glycosylation site is in the second half of the P-glycoprotein, the second glycosylation site links transmembrane domains 8 and 9 in the traditional model of the P-glycoprotein topology Mus musculus
7.6.2.2 glycoprotein one glycosylation site is in the second half of the P-glycoprotein, the second glycosylation site links transmembrane domains 8 and 9 in the traditional model of the P-glycoprotein topology Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 RPMI-8226 cell RPMI 8226 myeloma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 colchicine/in + ATP + H2O
-
 Homo sapiens colchicine/out + ADP + phosphate
-
 ?
7.6.2.2 doxorubicin/in + ATP + H2O
-
 Homo sapiens doxorubicin/out + ADP + phosphate
-
 ?
7.6.2.2 leukotriene C4/in + ATP + H2O
-
 Mus musculus leukotriene C4/out + ADP + phosphate
-
 ?
7.6.2.2 leukotriene C4/in + ATP + H2O
-
 Homo sapiens leukotriene C4/out + ADP + phosphate
-
 ?
7.6.2.2 leukotriene D4/in + ATP + H2O
-
 Homo sapiens leukotriene D4/out + ADP + phosphate
-
 ?
7.6.2.2 leukotriene E4/in + ATP + H2O
-
 Homo sapiens leukotriene E4/out + ADP + phosphate
-
 ?
7.6.2.2 additional information energy-dependent drug efflux pump Mus musculus ?
-
 ?
7.6.2.2 additional information energy-dependent drug efflux pump Homo sapiens ?
-
 ?
7.6.2.2 S-(2,4-dinitrophenyl)glutathione/in + ATP + H2O
-
 Homo sapiens S-(2,4-dinitrophenyl)glutathione/out + ADP + phosphate
-
 ?
7.6.2.2 vincristine/in + ATP + H2O
-
 Mus musculus vincristine/out + ADP + phosphate
-
 ?
7.6.2.2 vincristine/in + ATP + H2O
-
 Homo sapiens vincristine/out + ADP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.2 ? 1 * 190000, MRP from lung cancer cell line, calculation from nucleotide sequence Homo sapiens
7.6.2.2 More the P-glycoprotein contains 12 transmembrane domains with 6 extracellular loops and 2 cytoplasmic ATP-binding domains Homo sapiens