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Literature summary extracted from

  • Howard, S.P.; Meiklejohn, H.G.; Shivak, D.; Jahagirdar, R.
    A TonB-like protein and a novel membrane protein containing an ATP-binding cassette function together in exotoxin secretion (1996), Mol. Microbiol., 22, 595-604.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.4.2.5 exeA, subcloned into pEI14b, expressed in Escherichia coli Aeromonas hydrophila

Protein Variants

EC Number Protein Variants Comment Organism
7.4.2.5 G55A mutation in the potential ATP-binding site in ExeA, decreased rate of aerolysin secretion Aeromonas hydrophila
7.4.2.5 G55D mutation in the potential ATP-binding site in ExeA, decreased rate of aerolysin secretion Aeromonas hydrophila
7.4.2.5 G55V mutation in the potential ATP-binding site in ExeA, decreased rate of aerolysin secretion Aeromonas hydrophila

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.4.2.5 membrane inner membrane detected by immunoblotting, ExeA, cytoplasmic domain with ATP-binding site Aeromonas hydrophila 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.5 ATP + H2O + aerolysin/in Aeromonas hydrophila
-
 ADP + phosphate + aerolysin/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.5 Aeromonas hydrophila
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.4.2.5 ExeA Aeromonas hydrophila

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.5 ATP + H2O + aerolysin/in
-
 Aeromonas hydrophila ADP + phosphate + aerolysin/out
-
 ?

Subunits

EC Number Subunits Comment Organism
7.4.2.5 More ABC transporter Aeromonas hydrophila
7.4.2.5 More ExeA, cytoplasmic domain with ATP-binding site Aeromonas hydrophila