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Literature summary extracted from

  • Penefsky, H.S.
    Mitochondrial and chloroplast ATPases (1974), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 10, 375-429.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.2.2 2,4-dinitrophenol stimulates Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.2.2 ADP
-
 Bos taurus
7.1.2.2 ADP
-
 Euglena gracilis
7.1.2.2 ADP
-
 Rattus norvegicus
7.1.2.2 ADP
-
 Spinacia oleracea
7.1.2.2 Aurovertin
-
 Bos taurus
7.1.2.2 Aurovertin
-
 Saccharomyces cerevisiae
7.1.2.2 I2
-
 Bos taurus
7.1.2.2 Mg2+ 0.3 mM, 50% inhibition of Ca2+-dependent activity Spinacia oleracea
7.1.2.2 N,N'-dicyclohexylcarbodiimide
-
 Bos taurus
7.1.2.2 N,N'-dicyclohexylcarbodiimide
-
 Saccharomyces cerevisiae
7.1.2.2 Tetranitromethane
-
 Bos taurus
7.1.2.2 Trypsin
-
 Euglena gracilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1.2.2 0.097
-
 ATP
-
 Euglena gracilis
7.1.2.2 0.11
-
 ATP 2-(N-morpholino)ethane sulfonic acid buffer Spinacia oleracea
7.1.2.2 0.25
-
 ATP
-
 Saccharomyces cerevisiae
7.1.2.2 0.315
-
 ATP pH 8, membrane-bound enzyme Bos taurus
7.1.2.2 0.79
-
 ATP pH 8, soluble enzyme Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.2.2 chloroplast
-
 Euglena gracilis 9507
-
7.1.2.2 chloroplast
-
 Spinacia oleracea 9507
-
7.1.2.2 mitochondrion
-
 Rattus norvegicus 5739
-
7.1.2.2 mitochondrion
-
 Saccharomyces cerevisiae 5739
-
7.1.2.2 mitochondrion
-
 Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.1.2.2 Ca2+ required Euglena gracilis
7.1.2.2 Ca2+ required Spinacia oleracea
7.1.2.2 Ca2+ can replace Mg2+ or Co2+ Bos taurus
7.1.2.2 Co2+ absolute requirement for a divalent metal ion, Mg2+ or Co2+ Bos taurus
7.1.2.2 Fe2+ can replace Mg2+ or Co2+ Bos taurus
7.1.2.2 Mg2+
-
 Spinacia oleracea
7.1.2.2 Mg2+ absolute requirement for a divalent metal ion, Mg2+ or Co2+ Bos taurus
7.1.2.2 Mn2+ can replace Mg2+ or Co2+ Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.1.2.2 5700
-
 subunits of F1, x * 54000 + x * 50000 + x * 33000 + x * 17000 + x * 5700, SDS-PAGE Bos taurus
7.1.2.2 13000
-
 x * 59000 + x * 56000 + x * 37000 + x * 17500 + x * 13000, SDS-PAGE Spinacia oleracea
7.1.2.2 17000
-
 subunits of F1, x * 54000 + x * 50000 + x * 33000 + x * 17000 + x * 5700, SDS-PAGE Bos taurus
7.1.2.2 17500
-
 x * 59000 + x * 56000 + x * 37000 + x * 17500 + x * 13000, SDS-PAGE Spinacia oleracea
7.1.2.2 33000
-
 subunits of F1, x * 54000 + x * 50000 + x * 33000 + x * 17000 + x * 5700, SDS-PAGE Bos taurus
7.1.2.2 37000
-
 x * 59000 + x * 56000 + x * 37000 + x * 17500 + x * 13000, SDS-PAGE Spinacia oleracea
7.1.2.2 50000
-
 subunits of F1, x * 54000 + x * 50000 + x * 33000 + x * 17000 + x * 5700, SDS-PAGE Bos taurus
7.1.2.2 54000
-
 subunits of F1, x * 54000 + x * 50000 + x * 33000 + x * 17000 + x * 5700, SDS-PAGE Bos taurus
7.1.2.2 56000
-
 x * 59000 + x * 56000 + x * 37000 + x * 17500 + x * 13000, SDS-PAGE Spinacia oleracea
7.1.2.2 59000
-
 x * 59000 + x * 56000 + x * 37000 + x * 17500 + x * 13000, SDS-PAGE Spinacia oleracea
7.1.2.2 325000
-
 equilibrium ultracentrifugation Spinacia oleracea
7.1.2.2 360000 384000 equilibrium sedimentation Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
7.1.2.2 Bos taurus
-
-
-
7.1.2.2 Euglena gracilis
-
-
-
7.1.2.2 Magnusiomyces magnusii
-
-
-
7.1.2.2 Rattus norvegicus
-
-
-
7.1.2.2 Saccharomyces cerevisiae
-
-
-
7.1.2.2 Spinacia oleracea
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.1.2.2 no modification tests for glucosamine, galactosamine and fatty acids in F1 are negative Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
7.1.2.2
-
 Rattus norvegicus
7.1.2.2
-
 Saccharomyces cerevisiae
7.1.2.2
-
 Bos taurus
7.1.2.2
-
 Spinacia oleracea

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.2.2 heart
-
 Rattus norvegicus
-
7.1.2.2 heart
-
 Bos taurus
-
7.1.2.2 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.1.2.2 100
-
-
 Bos taurus

Storage Stability

EC Number Storage Stability Organism
7.1.2.2 22°C, 0.25 M sucrose, 2 mM EDTA, 4 mM ATP, 50 mM Tris-sulfate, pH 8, stable for several days Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.2.2 ATP + H2O + H+/in
-
 Rattus norvegicus ADP + phosphate + H+/out
-
 ?
7.1.2.2 ATP + H2O + H+/in
-
 Saccharomyces cerevisiae ADP + phosphate + H+/out
-
 ?
7.1.2.2 ATP + H2O + H+/in
-
 Bos taurus ADP + phosphate + H+/out
-
 ?
7.1.2.2 ATP + H2O + H+/in
-
 Euglena gracilis ADP + phosphate + H+/out
-
 ?
7.1.2.2 ATP + H2O + H+/in
-
 Spinacia oleracea ADP + phosphate + H+/out
-
 ?
7.1.2.2 ATP + H2O + H+/in
-
 Magnusiomyces magnusii ADP + phosphate + H+/out
-
 ?
7.1.2.2 dATP + H2O + H+/in
-
 Euglena gracilis dADP + phosphate + H+/out
-
 ?
7.1.2.2 GTP + H2O + H+/in
-
 Rattus norvegicus GDP + phosphate + H+/out
-
 ?
7.1.2.2 GTP + H2O + H+/in
-
 Bos taurus GDP + phosphate + H+/out
-
 ?
7.1.2.2 GTP + H2O + H+/in
-
 Euglena gracilis GDP + phosphate + H+/out
-
 ?
7.1.2.2 GTP + H2O + H+/in 17% of the activity with ATP Spinacia oleracea GDP + phosphate + H+/out
-
 ?
7.1.2.2 ITP + H2O + H+/in
-
 Rattus norvegicus IDP + phosphate + H+/out
-
 ?
7.1.2.2 ITP + H2O + H+/in
-
 Bos taurus IDP + phosphate + H+/out
-
 ?
7.1.2.2 ITP + H2O + H+/in
-
 Euglena gracilis IDP + phosphate + H+/out
-
 ?
7.1.2.2 ITP + H2O + H+/in 17% of the activity with ATP Spinacia oleracea IDP + phosphate + H+/out
-
 ?
7.1.2.2 UTP + H2O + H+/in
-
 Bos taurus UDP + phosphate + H+/out
-
 ?
7.1.2.2 UTP + H2O + H+/in 3% of the activity with ATP Spinacia oleracea UDP + phosphate + H+/out
-
 ?

Subunits

EC Number Subunits Comment Organism
7.1.2.2 ? subunits of F1, x * 54000 + x * 50000 + x * 33000 + x * 17000 + x * 5700, SDS-PAGE Bos taurus
7.1.2.2 ? x * 59000 + x * 56000 + x * 37000 + x * 17500 + x * 13000, SDS-PAGE Spinacia oleracea
7.1.2.2 More
-
 Rattus norvegicus
7.1.2.2 More
-
 Saccharomyces cerevisiae
7.1.2.2 More
-
 Bos taurus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
7.1.2.2 additional information
-
 dissociation of the enzyme molecule at low temperatures, protection by chloroplast lipids Spinacia oleracea
7.1.2.2 additional information
-
 enzyme is stable in the cold Euglena gracilis
7.1.2.2
-
 10
-
 Euglena gracilis
7.1.2.2
-
 10
-
 Spinacia oleracea
7.1.2.2
-
 10 dissociation and loss of activity at low temperatures is accelerated in increasing order by I-, NO3-, Br-, Cl-, SO42- Bos taurus