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Literature summary extracted from

  • Kettlun, A.M.; Alvarez, A.; Quintar, R.; Valenzuela, M.A.; Collados, L.; Aranda, E.; Banda, A.; Chayet, L.; Chiong, M.; Mancilla, M.; Traverso-Cori, A.
    Human placental ATP-diphosphohydrolase: biochemical characterization, regulation and function (1994), Int. J. Biochem., 26, 437-448.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.6.1.5 inactivated by Tween 20 Homo sapiens
3.6.1.5 unstable to detergent Triton X-100 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.5 CDTA
-
Homo sapiens
3.6.1.5 dicylcohexylcarbodiimid DCCD, slightly inhibited Homo sapiens
3.6.1.5 EDTA
-
Homo sapiens
3.6.1.5 EGTA
-
Homo sapiens
3.6.1.5 additional information no inhibition by Ap5A; no inhibition by ouabain Homo sapiens
3.6.1.5 orthovanadate
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.5 membrane membrane-bound Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.5 Ca2+ maximum activity at 0.5 mM Homo sapiens
3.6.1.5 Ca2+ Ca2+ preferred to Mg2+ Homo sapiens
3.6.1.5 Mg2+ Mg2+ preferred to Mn2+ Homo sapiens
3.6.1.5 Mn2+ preferred to Zn2+ Homo sapiens
3.6.1.5 Zn2+ preferred to Co2+ Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.5 60500
-
radiation-inactivation, ADPase Homo sapiens
3.6.1.5 62700
-
radiation-inactivation, ATPase Homo sapiens
3.6.1.5 64000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.5 ADP + H2O Homo sapiens
-
AMP + phosphate
-
?
3.6.1.5 ATP + 2 H2O Homo sapiens inhibition of platelet aggregation in the placenta AMP + 2 phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.5 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.6.1.5 glycoprotein interaction with concanavalin-A Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.5 placenta
-
Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.6.1.5 4°C, octylglucoside, stable Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.5 ADP + H2O
-
Homo sapiens AMP + phosphate
-
?
3.6.1.5 ATP + 2 H2O
-
Homo sapiens AMP + 2 phosphate
-
?
3.6.1.5 ATP + 2 H2O inhibition of platelet aggregation in the placenta Homo sapiens AMP + 2 phosphate
-
?
3.6.1.5 CDP + H2O
-
Homo sapiens CMP + phosphate
-
?
3.6.1.5 CTP + 2 H2O
-
Homo sapiens CMP + 2 phosphate
-
?
3.6.1.5 GDP + H2O
-
Homo sapiens GMP + phosphate
-
?
3.6.1.5 GTP + 2 H2O
-
Homo sapiens GMP + 2 phosphate
-
?
3.6.1.5 TDP + H2O
-
Homo sapiens TMP + phosphate
-
?
3.6.1.5 TTP + 2 H2O
-
Homo sapiens TMP + 2 phosphate
-
?
3.6.1.5 UDP + H2O
-
Homo sapiens UMP + phosphate
-
?
3.6.1.5 UTP + 2 H2O
-
Homo sapiens UMP + 2 phosphate
-
?