Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dahlmann, N.
    Human serum thymidine triphosphate nucleotidohydrolase: purification and properties of a new enzyme (1982), Biochemistry, 21, 6634-6639.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.39 EDTA with 0.2-2.0 mM EDTA 80% loss of activity Homo sapiens
3.6.1.39 Zn2+ causes complete inhibition in absence of EDTA Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.39 0.04
-
dTTP
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.39 Ca2+
-
Homo sapiens
3.6.1.39 Mg2+
-
Homo sapiens
3.6.1.39 Mn2+ reverses inhibitory effect of EDTA Homo sapiens
3.6.1.39 Zn2+
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.39 24000
-
SDS-PAGE Homo sapiens
3.6.1.39 48500
-
gel filtration and sucrose density gradient centrifugation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.39 dTTP + H2O Homo sapiens
-
dTDP + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.39 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.39 purified to homogenity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.39 serum
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.39 dTTP + H2O
-
Homo sapiens dTDP + phosphate
-
?
3.6.1.39 dUTP + H2O 50% activity compared with dTTP as substrate Homo sapiens dUDP + phosphate
-
?
3.6.1.39 UTP + H2O 20% activity compared with dTTP as substrate Homo sapiens UDP + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.6.1.39 dimer 2 * 24000, SDS-Page, gel filtration Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.6.1.39 12 23 no loss of activity within 1 h Homo sapiens
3.6.1.39 30 37 stability starts to decline above 30°C and breaks down at 37°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.39 7 9
-
Homo sapiens