BRENDA - Enzyme Database

Dinucleosidetetraphosphatase inhibition by Zn(II)

Cameselle, J.C.; Costas, M.J.; Sillero, M.A.G.; Sillero, A.; Biochem. Biophys. Res. Commun. 113, 717-722 (1983)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.6.1.17
EDTA
able to reverse Zn2+ inhibition
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
Zn2+
non-competitive, reversible with EDTA, very strong inhibitor
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.6.1.17
0.007
-
P1,P4-bis(5'-adenosyl) tetraphosphate
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.6.1.17
cytosol
-
Rattus norvegicus
5829
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.6.1.17
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.6.1.17
partial
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209900
Rattus norvegicus
ATP + AMP
-
-
-
-
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.6.1.17
EDTA
able to reverse Zn2+ inhibition
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
Zn2+
non-competitive, reversible with EDTA, very strong inhibitor
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.6.1.17
0.007
-
P1,P4-bis(5'-adenosyl) tetraphosphate
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.6.1.17
cytosol
-
Rattus norvegicus
5829
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.6.1.17
partial
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
209900
Rattus norvegicus
ATP + AMP
-
-
-
-